| 1303134 | Abca7 | ATP binding cassette subfamily A member 7 | ENCODES a protein that exhibits apolipoprotein A-I receptor activity (ortholog); floppase activity (ortholog); phosphatidylcholine floppase activity (ortholog); INVOLVED IN amyloid-beta clearance by cellular catabolic process (ortholog); amyloid-beta formation (ortholog); apolipoprotein A-I-mediated signaling pathway (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 9 (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); cell junction (ortholog); cell surface (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 7 | 10342092 | 10362094 | Rat | 214 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1552857 | Abca7 | ATP-binding cassette, sub-family A member 7 | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This pr otein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is widely expressed with highest detection in spleen and hematopoietic tissues. Defects in this gene cause an increase in amyloid-beta deposits in a mouse model of Alzheimer's disease, and a related human protein is thought to play a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jan 2017] | 10 | 79832328 | 79851406 | Mouse | 180 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1601775 | ABCA7 | ATP binding cassette subfamily A member 7 | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This p rotein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008] | 19 | 1040107 | 1065572 | Human | 213 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8824148 | Abca7 | ATP binding cassette subfamily A member 7 | ENCODES a protein that exhibits apolipoprotein A-I receptor activity (ortholog); floppase activity (ortholog); phosphatidylcholine floppase activity (ortholog); INVOLVED IN amyloid-beta clearance by cellular catabolic process (ortholog); amyloid-beta formation (ortholog); apolipoprotein A-I-mediated signaling pathway (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 9 (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); cell junction (ortholog); cell surface (ortholog) | NW_004955495 | 6818002 | 6838177 | Chinchilla | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12048533 | ABCA7 | ATP binding cassette subfamily A member 7 | ENCODES a protein that exhibits ABC-type transporter activity (inferred); apolipoprotein A-I receptor activity (inferred); ATP binding (inferred); INVOLVED IN amyloid-beta clearance by cellular catabolic process (ortholog); memory (ortholog); negative regulation of amyloid precursor protein biosynth etic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 9 (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); glial cell projection (ortholog) | 19 | 62811 | 77897 | Bonobo | 79 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12390353 | ABCA7 | ATP binding cassette subfamily A member 7 | ENCODES a protein that exhibits ABC-type transporter activity (inferred); apolipoprotein A-I receptor activity (inferred); ATP binding (inferred); INVOLVED IN amyloid-beta clearance by cellular catabolic process (ortholog); memory (ortholog); negative regulation of amyloid precursor protein biosynth etic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 9 (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog) | 20 | 57668371 | 57684111 | Dog | 64 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12487102 | Abca7 | ATP binding cassette subfamily A member 7 | ENCODES a protein that exhibits ABC-type transporter activity (inferred); apolipoprotein A-I receptor activity (inferred); ATP binding (inferred); INVOLVED IN amyloid-beta clearance by cellular catabolic process (ortholog); memory (ortholog); negative regulation of amyloid precursor protein biosynth etic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 9 (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog) | NW_004936588 | 460308 | 477382 | Squirrel | 66 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13960878 | ABCA7 | ATP binding cassette subfamily A member 7 | ENCODES a protein that exhibits ABC-type transporter activity (inferred); apolipoprotein A-I receptor activity (inferred); ATP binding (inferred); INVOLVED IN amyloid-beta clearance by cellular catabolic process (ortholog); memory (ortholog); negative regulation of amyloid precursor protein biosynth etic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 9 (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); glial cell projection (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18651930 | ABCA7 | ATP binding cassette subfamily A member 7 | ENCODES a protein that exhibits ABC-type transporter activity (inferred); apolipoprotein A-I receptor activity (inferred); ATP binding (inferred); INVOLVED IN amyloid-beta clearance by cellular catabolic process (ortholog); memory (ortholog); negative regulation of amyloid precursor protein biosynth etic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 9 (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); glial cell projection (ortholog) | | | | Green Monkey | 79 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626006797 | Abca7 | ATP binding cassette subfamily A member 7 | ENCODES a protein that exhibits apolipoprotein A-I receptor activity (ortholog); floppase activity (ortholog); phosphatidylcholine floppase activity (ortholog); INVOLVED IN amyloid-beta clearance by cellular catabolic process (ortholog); amyloid-beta formation (ortholog); apolipoprotein A-I-mediated signaling pathway (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 9 (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); cell junction (ortholog); cell surface (ortholog) | | | | Black Rat | 58 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18903374 | Abca7 | ATP binding cassette subfamily A member 7 | ENCODES a protein that exhibits floppase activity (ortholog); INVOLVED IN amyloid-beta clearance by cellular catabolic process (ortholog); high-density lipoprotein particle assembly (ortholog); memory (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 9 (ortholog); amyot rophic lateral sclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); cell junction (ortholog); cell surface (ortholog) | | | | Naked Mole-Rat | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |