| 2006 | Aanat | aralkylamine N-acetyltransferase | ENCODES a protein that exhibits 14-3-3 protein binding; aralkylamine N-acetyltransferase activity; arylamine N-acetyltransferase activity (ortholog); INVOLVED IN circadian rhythm; photoperiodism; response to calcium ion; PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH Experimental Diab etes Mellitus; type 2 diabetes mellitus; advanced sleep phase syndrome (ortholog); FOUND IN cytosol (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH (R)-noradrenaline; ammonium chloride; bisphenol A | 10 | 102323647 | 102330639 | Rat | 97 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 736736 | AANAT | aralkylamine N-acetyltransferase | The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] | 17 | 76453351 | 76470117 | Human | 99 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736737 | Aanat | arylalkylamine N-acetyltransferase | The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010] | 11 | 116482547 | 116489022 | Mouse | 114 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8775972 | Aanat | aralkylamine N-acetyltransferase | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); aralkylamine N-acetyltransferase activity (ortholog); arylamine N-acetyltransferase activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); circadian rhythm (ortholog); melatonin biosynthetic process (ortholog); PARTIC IPATES IN tryptophan metabolic pathway; ASSOCIATED WITH advanced sleep phase syndrome (ortholog); delayed sleep phase syndrome (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytosol (ortholog); perinuclear region of cytoplasm (ortholog) | NW_004955506 | 5828666 | 5834812 | Chinchilla | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11809805 | AANAT | aralkylamine N-acetyltransferase | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); aralkylamine N-acetyltransferase activity (ortholog); INVOLVED IN circadian rhythm (ortholog); N-terminal protein amino acid acetylation (ortholog); photoperiodism (ortholog); PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH advanced sleep phase syndrome (ortholog); delayed sleep phase syndrome (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); perinuclear region of cytoplasm (inferred) | 17 | 70401103 | 70418551 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12266941 | AANAT | aralkylamine N-acetyltransferase | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); aralkylamine N-acetyltransferase activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); circadian rhythm (ortholog); melatonin biosynthetic process (ortholog); PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH advanced sleep phase syndrome (ortholog); delayed sleep phase syndrome (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog) | 9 | 4238814 | 4245660 | Dog | 47 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12546070 | Aanat | aralkylamine N-acetyltransferase | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); aralkylamine N-acetyltransferase activity (ortholog); INVOLVED IN circadian rhythm (ortholog); N-terminal protein amino acid acetylation (ortholog); photoperiodism (ortholog); PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH advanced sleep phase syndrome (ortholog); delayed sleep phase syndrome (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); perinuclear region of cytoplasm (inferred) | NW_004936594 | 1556303 | 1559198 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907820 | Aanat | aralkylamine N-acetyltransferase | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); aralkylamine N-acetyltransferase activity (ortholog); arylamine N-acetyltransferase activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); circadian rhythm (ortholog); melatonin biosynthetic process (ortholog); PARTIC IPATES IN tryptophan metabolic pathway; ASSOCIATED WITH advanced sleep phase syndrome (ortholog); delayed sleep phase syndrome (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytosol (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Naked Mole-Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625850410 | Aanat | aralkylamine N-acetyltransferase | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); aralkylamine N-acetyltransferase activity (ortholog); arylamine N-acetyltransferase activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); circadian rhythm (ortholog); melatonin biosynthetic process (ortholog); PARTIC IPATES IN tryptophan metabolic pathway; ASSOCIATED WITH advanced sleep phase syndrome (ortholog); delayed sleep phase syndrome (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytosol (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Black Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18546656 | AANAT | aralkylamine N-acetyltransferase | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); aralkylamine N-acetyltransferase activity (ortholog); INVOLVED IN circadian rhythm (ortholog); N-terminal protein amino acid acetylation (ortholog); photoperiodism (ortholog); PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH advanced sleep phase syndrome (ortholog); delayed sleep phase syndrome (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); perinuclear region of cytoplasm (inferred) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232126 | aanat | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155257264 | aanat.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232125 | aanat.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14220732 | LOC100518330 | serotonin N-acetyltransferase | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); aralkylamine N-acetyltransferase activity (ortholog); INVOLVED IN circadian rhythm (ortholog); N-terminal protein amino acid acetylation (ortholog); photoperiodism (ortholog); PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH advanced sleep phase syndrome (ortholog); delayed sleep phase syndrome (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); perinuclear region of cytoplasm (inferred) | | | | Pig | 42 | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14371903 | AANAT1 | | | | | | Fly | | symbol | gene, null |
| 14371908 | AANATL2 | | | | | | Fly | | symbol | gene, null |
| 598276926 | AANATL2 | | | | | | Fly | | symbol | gene, null |
| 598277114 | AANATL2 | | | | | | Fly | | symbol | gene, null |
| 598277117 | AANATL2 | | | | | | Fly | | symbol | gene, null |
| 14371911 | AANATL3 | | | | | | Fly | | symbol | gene, null |
| 14371912 | AANATL4 | | | | | | Fly | | symbol | gene, null |
| 598152660 | AANATL5 | | | | | | Fly | | symbol | gene, null |
| 14371913 | AANATL5 | | | | | | Fly | | symbol | gene, null |
| 14371914 | AANATL6 | | | | | | Fly | | symbol | gene, null |
| 598150925 | AANATL6 | | | | | | Fly | | symbol | gene, null |
| 598151870 | AANATL6 | | | | | | Fly | | symbol | gene, null |
| 14371915 | AANATL7 | | | | | | Fly | | symbol | gene, null |