AANAT (aralkylamine N-acetyltransferase) - Rat Genome Database

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Gene: AANAT (aralkylamine N-acetyltransferase) Canis lupus familiaris
Analyze
Symbol: AANAT
Name: aralkylamine N-acetyltransferase
RGD ID: 12266941
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); aralkylamine N-acetyltransferase activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); circadian rhythm (ortholog); melatonin biosynthetic process (ortholog); PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH advanced sleep phase syndrome (ortholog); delayed sleep phase syndrome (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arylalkylamine N-acetyltransferase; serotonin N-acetyltransferase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,238,814 - 4,245,660 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,239,284 - 4,240,707 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha94,920,559 - 4,921,982 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.094,914,638 - 4,921,709 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,914,649 - 4,921,521 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.194,940,312 - 4,941,735 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,060,146 - 5,061,569 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,141,399 - 5,142,822 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16859891   PMID:17164235   PMID:30032202  


Genomics

Comparative Map Data
AANAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,238,814 - 4,245,660 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,239,284 - 4,240,707 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha94,920,559 - 4,921,982 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.094,914,638 - 4,921,709 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,914,649 - 4,921,521 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.194,940,312 - 4,941,735 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,060,146 - 5,061,569 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,141,399 - 5,142,822 (-)NCBIUU_Cfam_GSD_1.0
AANAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,453,351 - 76,470,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1776,453,351 - 76,470,117 (+)EnsemblGRCh38hg38GRCh38
GRCh371774,449,433 - 74,466,199 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,975,246 - 71,977,794 (+)NCBINCBI36Build 36hg18NCBI36
Build 341771,975,245 - 71,977,793NCBI
Celera1771,041,811 - 71,058,583 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1769,877,340 - 69,894,101 (+)NCBIHuRef
CHM1_11774,514,431 - 74,531,198 (+)NCBICHM1_1
T2T-CHM13v2.01777,349,434 - 77,366,693 (+)NCBIT2T-CHM13v2.0
Aanat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,482,547 - 116,489,022 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,477,258 - 116,488,506 (+)EnsemblGRCm39 Ensembl
GRCm3811116,591,721 - 116,597,680 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,586,432 - 116,597,680 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711116,455,001 - 116,458,994 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,409,777 - 116,413,634 (+)NCBIMGSCv36mm8
Celera11128,363,982 - 128,367,985 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.43NCBI
Aanat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,323,647 - 102,330,639 (+)NCBIGRCr8
mRatBN7.210101,827,072 - 101,831,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,827,301 - 101,831,801 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,883,977 - 106,888,805 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,347,070 - 106,351,898 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,748,363 - 101,752,675 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,568,091 - 105,572,407 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,568,091 - 105,572,403 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,231,006 - 105,235,322 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,709,371 - 106,713,683 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,723,787 - 106,728,187 (+)NCBI
Celera10100,399,613 - 100,403,925 (+)NCBICelera
Cytogenetic Map10q32.2NCBI
Aanat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555065,828,659 - 5,834,812 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555065,828,666 - 5,834,812 (-)NCBIChiLan1.0ChiLan1.0
AANAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21992,495,416 - 92,513,399 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11797,321,123 - 97,338,596 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01770,401,103 - 70,418,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11775,951,915 - 75,967,411 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1775,951,915 - 75,967,411 (+)Ensemblpanpan1.1panPan2
Aanat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,852,759 - 4,869,231 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,556,285 - 1,559,400 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,556,303 - 1,559,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100518330
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,042,897 - 5,044,505 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,042,897 - 5,047,626 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2124,887,637 - 4,897,028 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AANAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,206,233 - 45,215,761 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,206,377 - 45,207,591 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607715,946,938 - 15,949,113 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aanat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248016,331,505 - 6,333,599 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248016,329,090 - 6,333,290 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AANAT
107 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 21 5 6 5 6 6 12 8 10 6
Low 1 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008185   ⟹   ENSCAFP00000007581
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl94,239,284 - 4,240,707 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845031175   ⟹   ENSCAFP00845024407
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl94,914,649 - 4,921,521 (-)Ensembl
RefSeq Acc Id: NM_001077437   ⟹   NP_001070905
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.194,239,284 - 4,240,707 (-)NCBI
Dog10K_Boxer_Tasha94,920,559 - 4,921,982 (-)NCBI
ROS_Cfam_1.094,915,126 - 4,916,549 (-)NCBI
UMICH_Zoey_3.194,940,312 - 4,941,735 (-)NCBI
UNSW_CanFamBas_1.095,060,146 - 5,061,569 (-)NCBI
UU_Cfam_GSD_1.095,141,399 - 5,142,822 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038675036   ⟹   XP_038530964
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.094,914,638 - 4,921,709 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001070905 (Get FASTA)   NCBI Sequence Viewer  
  XP_038530964 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABC74871 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000007581.4
  ENSCAFP00030002394.1
  ENSCAFP00040000374.1
  ENSCAFP00845024407
  ENSCAFP00845024407.1
Reference Protein Sequences
RefSeq Acc Id: NP_001070905   ⟸   NM_001077437
- UniProtKB: Q00M96 (UniProtKB/TrEMBL),   F6PK10 (UniProtKB/TrEMBL),   A0A8C0JYV8 (UniProtKB/TrEMBL),   A0A8C0M2E5 (UniProtKB/TrEMBL),   A0A8C0JZV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000007581   ⟸   ENSCAFT00000008185
RefSeq Acc Id: XP_038530964   ⟸   XM_038675036
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RZZ3 (UniProtKB/TrEMBL),   A0A8P0N7W5 (UniProtKB/TrEMBL),   A0A8C0PLY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845024407   ⟸   ENSCAFT00845031175
Protein Domains
N-acetyltransferase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005090 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001496 UniProtKB/TrEMBL
  ENSCAFG00040000276 UniProtKB/TrEMBL
  ENSCAFG00845017611 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008185.4 UniProtKB/TrEMBL
  ENSCAFT00030002684.1 UniProtKB/TrEMBL
  ENSCAFT00040000458.1 UniProtKB/TrEMBL
  ENSCAFT00845031175 ENTREZGENE
  ENSCAFT00845031175.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.30 UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  GNAT_dom UniProtKB/TrEMBL
KEGG Report cfa:483331 UniProtKB/TrEMBL
NCBI Gene AANAT ENTREZGENE
PANTHER SEROTONIN N-ACETYLTRANSFERASE UniProtKB/TrEMBL
  SEROTONIN N-ACETYLTRANSFERASE UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/TrEMBL
PROSITE GNAT UniProtKB/TrEMBL
Superfamily-SCOP SSF55729 UniProtKB/TrEMBL
UniProt A0A8C0JYV8 ENTREZGENE
  A0A8C0JZV2 ENTREZGENE
  A0A8C0M2E5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PLY1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RZZ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N7W5 ENTREZGENE, UniProtKB/TrEMBL
  F6PK10 ENTREZGENE
  Q00M96 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F6PK10 UniProtKB/TrEMBL
VGNC ID VGNC:37413 ENTREZGENE