Gene: AANAT (aralkylamine N-acetyltransferase) Homo sapiens
Symbol: AANAT
Name: aralkylamine N-acetyltransferase
Description: The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA-NAT; arylalkylamine n - acetyltransferase; arylalkylamine N-acetyltransferase; DSPS; serotonin acetylase; serotonin N-acetyltransferase; SNAT
Mus musculus (house mouse) : Aanat (arylalkylamine N-acetyltransferase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aanat (aralkylamine N-acetyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aanat (aralkylamine N-acetyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : AANAT (aralkylamine N-acetyltransferase)
Canis lupus familiaris (dog) : AANAT (aralkylamine N-acetyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aanat (aralkylamine N-acetyltransferase)
Sus scrofa (pig) : LOC100518330 (serotonin N-acetyltransferase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381776,453,351 - 76,470,797 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371774,449,433 - 74,466,199 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,975,246 - 71,977,794 (+)NCBINCBI36hg18NCBI36
Build 341771,975,245 - 71,977,793NCBI
Celera1771,041,811 - 71,058,583 (+)NCBI
Cytogenetic Map17q25.1NCBI
HuRef1769,877,340 - 69,894,101 (+)NCBIHuRef
CHM1_11774,514,431 - 74,531,198 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AANAT
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736736
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-02-05
Status: ACTIVE