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Strain Registration

Strain: SHR.BN-(Il6-Npy)

Symbol: SHR.BN-(Il6-Npy)
Strain: SHR.BN-(Il6-Npy)
RGD ID: 629502
Citation ID: RRID:RGD_629502
Ontology ID: RS:0000726
Also Known As: SHR.BN-(Il6-Npy); SHR.4
Type: congenic
Available Source: Not Available
Origination: MRC Clinical Centre, London, UK
Description: This congenic carries a chromosome 4 segment derived from BN/Crl (Charles River) and repeated backcross to SHR/NCruk and selection for Il6 and Npy heterozygotes
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr845,889,999 - 80,219,310RGD_MAPPER_PIPELINE
mRatBN7.245,214,602 - 78,888,495RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.043,043,231 - 79,565,059RGD_MAPPER_PIPELINERnor6.0
Rnor_5.043,095,536 - 144,240,956RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.44456,799 - 78,045,187RGD_MAPPER_PIPELINERGSC3.4





Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SHR.BN-(Il6-Npy)Ratdecreased systemic arterial blood pressure  IMP 2300254as compared to SHR progenitorRGD 
SHR.BN-(Il6-Npy)Ratincreased adipocyte glucose uptake  IAGP 619666compared to SHRRGD 

#
Reference Title
Reference Citation
1. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Aitman TJ, etal., Nat Genet 1999 Jan;21(1):76-83.
2. Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Pravenec M, etal., Nat Genet. 2008 Aug;40(8):952-4. Epub 2008 Jun 29.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines



Flank 1 / 1 (Il6)
Rat AssemblyChrPosition (strand)Source
GRCr845,889,999 - 5,894,575 (-)NCBI
mRatBN7.245,214,602 - 5,219,178 (-)NCBI
mRatBN7.2 Ensembl45,213,394 - 5,219,178 (-)Ensembl
UTH_Rnor_SHR_Utx410,211,864 - 10,216,458 (-)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.046,026,101 - 6,030,695 (-)NCBI
UTH_Rnor_WKY_Bbb_1.044,372,235 - 4,376,829 (-)NCBI
Rnor_6.043,043,231 - 3,047,807 (+)NCBI
Rnor_6.0 Ensembl43,043,231 - 3,047,807 (+)Ensembl
Rnor_5.043,095,536 - 3,100,112 (+)NCBI
RGSC_v3.44456,799 - 461,376 (-)NCBI
RGSC_v3.14456,798 - 461,376 (-)NCBI
Celera45,093,593 - 5,098,169 (+)NCBI
Cytogenetic Map4q11NCBI

Flank 2 / 1 (Npy)
Rat AssemblyChrPosition (strand)Source
GRCr8480,212,111 - 80,219,310 (+)NCBI
mRatBN7.2478,881,294 - 78,888,495 (+)NCBI
mRatBN7.2 Ensembl478,881,264 - 78,888,495 (+)Ensembl
UTH_Rnor_SHR_Utx484,098,422 - 84,105,619 (+)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.0479,873,911 - 79,881,112 (+)NCBI
UTH_Rnor_WKY_Bbb_1.0478,314,242 - 78,321,437 (+)NCBI
Rnor_6.0479,557,856 - 79,565,059 (+)NCBI
Rnor_6.0 Ensembl479,557,854 - 79,565,097 (+)Ensembl
Rnor_6.0 Ensembl479,573,998 - 79,581,208 (+)Ensembl
Rnor_5.04144,233,753 - 144,240,956 (+)NCBI
RGSC_v3.4478,038,013 - 78,045,187 (+)NCBI
RGSC_v3.1478,314,142 - 78,321,317 (+)NCBI
Celera473,795,148 - 73,802,371 (+)NCBI
RH 3.4 Map4508.6RGD
RH 3.4 Map4507.8RGD
Cytogenetic Map4q24NCBI


Note Type Note Reference
strain_characteristics Displays partial correction of the SHR defect in insulin-mediated glucose uptake and complete correction of isoproterenol-mediated lipolysis. 619666