RGD Reference Report - Estrogen receptor beta mRNA expression in normal and adenomatous pituitaries. - Rat Genome Database

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Estrogen receptor beta mRNA expression in normal and adenomatous pituitaries.

Authors: Gittoes, NJ  McCabe, CJ  Sheppard, MC  Franklyn, JA 
Citation: Gittoes NJ, etal., Pituitary. 1999;1(2):99-104.
RGD ID: 8694115
Pubmed: PMID:11081187   (View Abstract at PubMed)

Estrogen (E2), acting via its nuclear receptors, has been implicated in tumor development and growth, particularly in the pathogenesis of breast cancer. E2 also modulates anterior pituitary hormone production and is a potent cell mitogen. Until recently, the actions of E2 were thought to be mediated by a single estrogen receptor (ER) isoform (ER alpha), and currently little is known of the pathophysiological relevance of the ER beta isoform. The presence of ER beta mRNA has been demonstrated by RT-PCR in the normal human pituitary, although expression of ER beta mRNA in human pituitary tumors has now been described. We have used semiquantitative RT-PCR to determine the relative levels of expression of ER beta mRNA in normal human pituitaries, non-functioning pituitary adenomas and GH-secreting tumors. ER beta mRNA was detected in normal pituitaries and all pituitary tumors examined. The ratio of ER beta mRNA to beta-actin mRNA expression was significantly reduced in non-functioning pituitary tumors (NFTs; 0.92 +/- 0.09; mean +/- SE; n = 23) compared with findings in normal pituitaries (1.56 +/- 0.21; mean +/- SE; n = 5; p < 0.05 Student's t-test). Studies of ER beta protein expression are required to determine the functional significance of reduced ER beta mRNA expression in NFTs.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ESR2HumanPituitary Neoplasms  IEP mRNA:decreased expression:pituitary gland (human)RGD 
Esr2RatPituitary Neoplasms  ISOESR2 (Homo sapiens)mRNA:decreased expression:pituitary gland (human)RGD 
Esr2MousePituitary Neoplasms  ISOESR2 (Homo sapiens)mRNA:decreased expression:pituitary gland (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Esr2  (estrogen receptor 2)

Genes (Mus musculus)
Esr2  (estrogen receptor 2 (beta))

Genes (Homo sapiens)
ESR2  (estrogen receptor 2)


Additional Information