RGD Reference Report - Regulation of the rat brain Na+ -driven Cl-/HCO3 - exchanger involves protein kinase A and a multiprotein signaling complex. - Rat Genome Database

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Regulation of the rat brain Na+ -driven Cl-/HCO3 - exchanger involves protein kinase A and a multiprotein signaling complex.

Authors: Lee, YS  Ouyang, YB  Giffard, RG 
Citation: Lee YS, etal., FEBS Lett. 2006 Sep 4;580(20):4865-71. Epub 2006 Aug 8.
RGD ID: 8554408
Pubmed: PMID:16916513   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2006.07.075   (Journal Full-text)

The Na(+)-driven Cl(-)/HCO(3)(-) exchanger (NCBE) plays an important role in the regulation of intracellular pH (pH(i)). We previously identified two variants of NCBE from rat brain of which the variant with a carboxyterminal PSD-95/Dlg/ZO-1 (PDZ) motif (rb2NCBE) colocalized with the actin cytoskeleton. Increased rb2NCBE activity by PKA inhibition and reduction by forskolin and cAMP agonist suggest PKA regulation of NCBE. Disruption of actin filaments also decreased rb2NCBE activity. EBP50 and FLAG-rb2NCBE were reciprocally co-immunoprecipitated from rb2NCBE transfected cells. It is concluded that NCBE activity is inhibited by PKA and depends on the integrity of the actin cytoskeleton within a multiprotein complex at the plasma membrane.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding enablesIPIUniProtKB:P704418554408PMID:16916513IntAct 

Objects Annotated

Genes (Rattus norvegicus)
Slc4a10  (solute carrier family 4 member 10)


Additional Information