RGD Reference Report - Association between chronic cutaneous lupus erythematosus and HLA class II alleles. - Rat Genome Database

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Association between chronic cutaneous lupus erythematosus and HLA class II alleles.

Authors: Fischer, GF  Pickl, WF  Fae, I  Anegg, B  Milota, S  Volc-Platzer, B 
Citation: Fischer GF, etal., Hum Immunol. 1994 Dec;41(4):280-4.
RGD ID: 8547567
Pubmed: PMID:7883595   (View Abstract at PubMed)

CCLE, a disease entity at the benign end of the lupus spectrum, is characterized by marked photosensitivity and skin lesions in sun-exposed areas. The histopathology of lesions resembles hypersensitivity type IV reactions. We have asked whether an association between class II alleles and CCLE exists. RFLP analysis of HLA-DQA genes revealed a Taq I HLA-DQA1 allelic restriction fragment overrepresented in a group consisting of 26 patients as compared to healthy control individuals. This result was corroborated by typing with oligonucleotide probes. The presence of the DQA1*0102 allele in the patients' group led to a relative risk of 4.57, with a statistical significance of p < 0.05 after correction for 36 comparisons. Although not statistically significant, it is interesting that all patients possess in at least one of their HLA-DQA1 alleles a nucleotide sequence coding for the amino acid glutamine at position 34 of the DQ alpha molecule. The expected frequency of these alleles in the control population amounts to 82%. The HLA-DRB1*16 allele, which is found in linkage disequilibrium with the HLA-DQA1*0102 allele, is also observed at an increased frequency in the patient's group, though the association was not significant after correction for the number of comparisons. However, no associations of CCLE with alleles at the HLA-DPB1 locus was found. The association of CCLE with certain HLA class II alleles points to an involvement of HLA-DQ and/or -DR molecules in the pathogenesis of the disease. Alternatively, genetic loci in linkage disequilibrium may code for elements which contribute to the development of CCLE.(ABSTRACT TRUNCATED AT 250 WORDS)



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
H2-AaMouseDiscoid Lupus Erythematosus susceptibilityISOHLA-DQA1 (Homo sapiens)DNA:polymorphism: :HLA-DQA1*0102RGD 
HLA-DQA1HumanDiscoid Lupus Erythematosus susceptibilityIAGP DNA:polymorphism: :HLA-DQA1*0102RGD 
RT1-BaRatDiscoid Lupus Erythematosus susceptibilityISOHLA-DQA1 (Homo sapiens)DNA:polymorphism: :HLA-DQA1*0102RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Ba  (RT1 class II, locus Ba)

Genes (Mus musculus)
H2-Aa  (histocompatibility 2, class II antigen A, alpha)

Genes (Homo sapiens)
HLA-DQA1  (major histocompatibility complex, class II, DQ alpha 1)


Additional Information