Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data. |
Authors: |
Randerson-Moor, JA Taylor, JC Elliott, F Chang, YM Beswick, S Kukalizch, K Affleck, P Leake, S Haynes, S Karpavicius, B Marsden, J Gerry, E Bale, L Bertram, C Field, H Barth, JH Silva Idos, S Swerdlow, A Kanetsky, PA Barrett, JH Bishop, DT Bishop, JA
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Citation: |
Randerson-Moor JA, etal., Eur J Cancer. 2009 Dec;45(18):3271-81. doi: 10.1016/j.ejca.2009.06.011. Epub 2009 Jul 15. |
RGD ID: |
8158071 |
Pubmed: |
PMID:19615888 (View Abstract at PubMed) |
PMCID: |
PMC2786912 (View Article at PubMed Central) |
DOI: |
DOI:10.1016/j.ejca.2009.06.011 (Journal Full-text) |
We have carried out melanoma case-control comparisons for six vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) and serum 25-hydroxyvitamin D(3) levels in order to investigate the role of vitamin D in melanoma susceptibility. There was no significant evidence of an association between any VDR SNP and risk in 1028 population-ascertained cases and 402 controls from Leeds, UK. In a second Leeds case-control study (299 cases and 560 controls) the FokI T allele was associated with increased melanoma risk (odds ratio (OR) 1.42, 95% confidence interval (CI) 1.06-1.91, p=0.02). In a meta-analysis in conjunction with published data from other smaller data sets (total 3769 cases and 3636 controls), the FokI T allele was associated with increased melanoma risk (OR 1.19, 95% CI 1.05-1.35), and the BsmI A allele was associated with a reduced risk (OR 0.81, 95% CI 0.72-0.92), in each instance under a parsimonious dominant model. In the first Leeds case-control comparison cases were more likely to have a higher body mass index (BMI) than controls (p=0.007 for linear trend). There was no evidence of a case-control difference in serum 25-hydroxyvitamin D(3) levels. In 1043 incident cases from the first Leeds case-control study, a single estimation of serum 25-hydroxyvitamin D(3) level taken at recruitment was inversely correlated with Breslow thickness (p=0.03 for linear trend). These data provide evidence to support the view that vitamin D and VDR may have a small but potentially important role in melanoma susceptibility, and putatively a greater role in disease progression.
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Manual Human Phenotype Annotations - RGD
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