RGD Reference Report - Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data. - Rat Genome Database

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Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data.

Authors: Randerson-Moor, JA  Taylor, JC  Elliott, F  Chang, YM  Beswick, S  Kukalizch, K  Affleck, P  Leake, S  Haynes, S  Karpavicius, B  Marsden, J  Gerry, E  Bale, L  Bertram, C  Field, H  Barth, JH  Silva Idos, S  Swerdlow, A  Kanetsky, PA  Barrett, JH  Bishop, DT  Bishop, JA 
Citation: Randerson-Moor JA, etal., Eur J Cancer. 2009 Dec;45(18):3271-81. doi: 10.1016/j.ejca.2009.06.011. Epub 2009 Jul 15.
RGD ID: 8158071
Pubmed: PMID:19615888   (View Abstract at PubMed)
PMCID: PMC2786912   (View Article at PubMed Central)
DOI: DOI:10.1016/j.ejca.2009.06.011   (Journal Full-text)

We have carried out melanoma case-control comparisons for six vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) and serum 25-hydroxyvitamin D(3) levels in order to investigate the role of vitamin D in melanoma susceptibility. There was no significant evidence of an association between any VDR SNP and risk in 1028 population-ascertained cases and 402 controls from Leeds, UK. In a second Leeds case-control study (299 cases and 560 controls) the FokI T allele was associated with increased melanoma risk (odds ratio (OR) 1.42, 95% confidence interval (CI) 1.06-1.91, p=0.02). In a meta-analysis in conjunction with published data from other smaller data sets (total 3769 cases and 3636 controls), the FokI T allele was associated with increased melanoma risk (OR 1.19, 95% CI 1.05-1.35), and the BsmI A allele was associated with a reduced risk (OR 0.81, 95% CI 0.72-0.92), in each instance under a parsimonious dominant model. In the first Leeds case-control comparison cases were more likely to have a higher body mass index (BMI) than controls (p=0.007 for linear trend). There was no evidence of a case-control difference in serum 25-hydroxyvitamin D(3) levels. In 1043 incident cases from the first Leeds case-control study, a single estimation of serum 25-hydroxyvitamin D(3) level taken at recruitment was inversely correlated with Breslow thickness (p=0.03 for linear trend). These data provide evidence to support the view that vitamin D and VDR may have a small but potentially important role in melanoma susceptibility, and putatively a greater role in disease progression.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
VDRHumanskin melanoma no_associationIAGP DNA:SNPs: :multipleRGD 
VdrRatskin melanoma no_associationISOVDR (Homo sapiens)DNA:SNPs: :multipleRGD 
VdrMouseskin melanoma no_associationISOVDR (Homo sapiens)DNA:SNPs: :multipleRGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
VDRHumanCutaneous melanoma no_associationIAGP DNA:SNPs: :multipleRGD 
Objects Annotated

Genes (Rattus norvegicus)
Vdr  (vitamin D receptor)

Genes (Mus musculus)
Vdr  (vitamin D (1,25-dihydroxyvitamin D3) receptor)

Genes (Homo sapiens)
VDR  (vitamin D receptor)