RGD Reference Report - Total Glucosides of Peony Attenuates 2,4,6-Trinitrobenzene Sulfonic Acid/Ethanol-Induced Colitis in Rats Through Adjustment of Th1/Th2 Cytokines Polarization.

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Total Glucosides of Peony Attenuates 2,4,6-Trinitrobenzene Sulfonic Acid/Ethanol-Induced Colitis in Rats Through Adjustment of Th1/Th2 Cytokines Polarization.
Authors:	Zhang, Y Zhou, R Zhou, F Cheng, H Xia, B
Citation:	Zhang Y, etal., Cell Biochem Biophys. 2013 Jun 15.
RGD ID:	7365024
Pubmed:	PMID:23771723 (View Abstract at PubMed)
DOI:	DOI:10.1007/s12013-013-9696-3 (Journal Full-text)
The present study is to investigate effects of total glucosides of peony (TGP) on 2,4,6-trinitrobenzene sulfonic acid (TNBS)/ethanol-induced colitis in rats and to explore potential clinical use of TGP for treatment of inflammatory bowel disease. Sixty Sprague-Dawley rats were randomly grouped into normal controls, model controls, sulfasalazine (SASP) controls (100 mg/kg/day), and low, medium, and high-dose TGP groups (25, 50, and 100 mg/kg/day, respectively). 24 h following colonic instillation of TNBS, TGP, and SASP were given by gastric gavage three times a day for 7 days. Disease activity index (DAI), colon macroscopic damage index (CMDI), histopathological score (HPS), and myeloperoxidase (MPO) activity were evaluated. Levels of serum TNF-alpha, IL-1beta, and IL-10 were measured by ELISA, and expression of TNF-alpha, IL-1beta, and IL-10 mRNA and protein in colonic tissues was detected by RT-PCR and western blot, respectively. Compared with rats in the model controls, TGP (50 or 100 mg/kg/day)-treated rats with TNBS/ethanol-induced colitis showed significant improvements of DAI, CMDI, HPS, and MPO activity. Moreover, administration of TGP (50 or 100 mg/kg/day) decreased the up-regulated levels of serum TNF-alpha and IL-1beta, and expression of TNF-alpha and IL-1beta mRNA and protein in colonic tissues, and increased the serum IL-10 and colonic IL-10 mRNA and protein level. And there was no significant difference compared with administration of SASP (P > 0.05). TGP attenuates TNBS/ethanol-induced colitis in rats and its efficacy is similar to SASP, the potential mechanism might be related to the adjustment of Th1/Th2 cytokines polarization by decreasing pro-inflammatory cytokine TNF-alpha and IL-1beta, and increasing anti-inflammatory cytokine IL-10.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
IL10	Human	colitis	treatment	ISO	Il10 (Rattus norvegicus)		RGD
Il10	Rat	colitis	treatment	IEP			RGD
Il10	Mouse	colitis	treatment	ISO	Il10 (Rattus norvegicus)		RGD

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Genes (Rattus norvegicus)

Il10 (interleukin 10)

Genes (Mus musculus)

Il10 (interleukin 10)

Genes (Homo sapiens)

IL10 (interleukin 10)

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Total Glucosides of Peony Attenuates 2,4,6-Trinitrobenzene Sulfonic Acid/Ethanol-Induced Colitis in Rats Through Adjustment of Th1/Th2 Cytokines Polarization.