RGD Reference Report - Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis. - Rat Genome Database

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Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis.

Authors: Fousteri, G  Dave, A  Morin, B  Omid, S  Croft, M  Von Herrath, MG 
Citation: Fousteri G, etal., J Autoimmun. 2011 May;36(3-4):210-20. doi: 10.1016/j.jaut.2011.01.006. Epub 2011 Feb 17.
RGD ID: 7364847
Pubmed: PMID:21333491   (View Abstract at PubMed)
PMCID: PMC3079777   (View Article at PubMed Central)
DOI: DOI:10.1016/j.jaut.2011.01.006   (Journal Full-text)

Myocarditis poses a severe health problem, can lead to dilated cardiomyopathy (DCM) and death, and is thought to be triggered by infections. Enteroviruses such as Coxsackie virus B3 (CVB3) have been implicated as a culprit, since they can cause acute and chronic heart disease in susceptible mice. CVB was detected in human cardiac myocytes in some cases, whereas acute CVB infection was thought to have caused death. Here we studied, whether nasal administration of cardiac myosin (CM) major histocompatibility class (MHC) II peptides CM(9)(4)(7)-(9)(6)(0) and CM(7)(3)(5)-(7)(4)(7) and OX40 blockade would be able to ameliorate immunopathology and heart disease in BALB/C mice infected with CVB3. We found that nasal CM-peptide prophylactic treatment significantly reduced myocarditis and mortality by enhancing Treg and IL-10 induction and that blockade of OX40 signaling could reduce heart inflammation when administered late during pathogenesis. Altogether, these results chart the way for novel prevention and intervention strategies for viral myocarditis.




  
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Original Reference(s)
IL10Humanmyocarditis treatmentISOIl10 (Mus musculus)associated with Coxsackievirus InfectionsRGD 
Il10Ratmyocarditis treatmentISOIl10 (Mus musculus)associated with Coxsackievirus InfectionsRGD 
Il10Mousemyocarditis treatmentIDA associated with Coxsackievirus InfectionsRGD 


Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)