RGD Reference Report - Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis. - Rat Genome Database

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Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis.

Authors: Summers, SA  Steinmetz, OM  Ooi, JD  Gan, PY  O'Sullivan, KM  Visvanathan, K  Akira, S  Kitching, AR  Holdsworth, SR 
Citation: Summers SA, etal., Am J Pathol. 2010 Nov;177(5):2234-44. doi: 10.2353/ajpath.2010.100153. Epub 2010 Sep 16.
RGD ID: 7246899
Pubmed: PMID:20847283   (View Abstract at PubMed)
PMCID: PMC2966783   (View Article at PubMed Central)
DOI: DOI:10.2353/ajpath.2010.100153   (Journal Full-text)

Glomerular disease can be triggered or exacerbated by microbes that activate the immune system by Toll-like receptor (TLR) ligation. TLR9 activation promotes host defenses through the enhancement of innate and adaptive immune responses that facilitate the recruitment of leukocytes to areas of inflammation. We defined the role of TLR9 in experimental crescentic glomerulonephritis. Wild-type mice administered a TLR9 ligand and sheep anti-mouse glomerular basement membrane antibody developed histological injury with impaired renal function, which was attenuated in TLR9 knockout mice. Consistent with enhanced renal injury, wild-type mice exhibited enhanced T helper 1 and T helper 17 cellular immune responses. Kidney mRNA expression of inflammatory cytokines and chemokines as well as leukocyte recruitment were increased in wild-type mice. The use of bone marrow chimeric mice demonstrated that while both bone marrow and tissue cell TLR9 are required for maximal injury, bone marrow TLR9 is more important. Administration of a TLR9 inhibitor before sheep anti-mouse glomerular basement membrane globulin in wild-type mice attenuated cellular nephritogenic immunity that resulted in decreased renal injury. Administration of the inhibitor 7 days after disease initiation decreased glomerular leukocyte recruitment as well as renal injury. These results define the role of TLR9 in experimental crescentic glomerulonephritis and identify therapeutic potential for TLR9 inhibitors in attenuating renal injury, decreasing cellular nephritogenic immunity early in disease, and decreasing kidney effector responses later.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TLR9Humancrescentic glomerulonephritis severityISOTlr9 (Mus musculus) RGD 
Tlr9Ratcrescentic glomerulonephritis severityISOTlr9 (Mus musculus) RGD 
Tlr9Mousecrescentic glomerulonephritis severityIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr9  (toll-like receptor 9)

Genes (Mus musculus)
Tlr9  (toll-like receptor 9)

Genes (Homo sapiens)
TLR9  (toll like receptor 9)


Additional Information