RGD Reference Report - Nonenzymatically glycated lipoprotein ApoA-I in plasma of diabetic and nephropathic patients. - Rat Genome Database

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Nonenzymatically glycated lipoprotein ApoA-I in plasma of diabetic and nephropathic patients.

Authors: Lapolla, A  Brioschi, M  Banfi, C  Tremoli, E  Cosma, C  Bonfante, L  Cristoni, S  Seraglia, R  Traldi, P 
Citation: Lapolla A, etal., Ann N Y Acad Sci. 2008 Apr;1126:295-9. Epub 2007 Dec 13.
RGD ID: 7241576
Pubmed: PMID:18079481   (View Abstract at PubMed)
DOI: DOI:10.1196/annals.1433.005   (Journal Full-text)

ApoA-I, which constitutes 70% of the apolipoprotein content of high-density lipoproteins, acts as an acceptor for the transfer of phospholipids and free cholesterol from peripheral tissues and transports cholesterol in the liver and other tissue for excretion and steroidogenesis. In order to verify its possible structural alteration in pathological states, plasma samples from healthy, diabetic, and nephropathic subjects have been analyzed by two-dimensional gel electrophoresis. By this approach, clear differences among the three classes of subjects become evident and, in the case of diabetic and nephropathic patients, intense spots are present. The matrix-assisted laser desorption/ionization mass spectrometry analysis of their digestion products shows that an overexpression of unglycated and glycated ApoA-I is present in both pathological states, reasonably affecting the efficiency in cholesterol transport.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
APOA1Humanend stage renal disease  IEP protein:increased expression and increased glycation:plasmaRGD 
Apoa1Ratend stage renal disease  ISOAPOA1 (Homo sapiens)protein:increased expression and increased glycation:plasmaRGD 
Apoa1Mouseend stage renal disease  ISOAPOA1 (Homo sapiens)protein:increased expression and increased glycation:plasmaRGD 
APOA1Humantype 2 diabetes mellitus  IEP protein:increased expression and increased glycation:plasmaRGD 
Apoa1Rattype 2 diabetes mellitus  ISOAPOA1 (Homo sapiens)protein:increased expression and increased glycation:plasmaRGD 
Apoa1Mousetype 2 diabetes mellitus  ISOAPOA1 (Homo sapiens)protein:increased expression and increased glycation:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoa1  (apolipoprotein A1)

Genes (Mus musculus)
Apoa1  (apolipoprotein A-I)

Genes (Homo sapiens)
APOA1  (apolipoprotein A1)


Additional Information