RGD Reference Report - RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. - Rat Genome Database

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RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.

Authors: Schoch, S  Castillo, PE  Jo, T  Mukherjee, K  Geppert, M  Wang, Y  Schmitz, F  Malenka, RC  Sudhof, TC 
Citation: Schoch S, etal., Nature 2002 Jan 17;415(6869):321-6.
RGD ID: 633666
Pubmed: PMID:11797009   (View Abstract at PubMed)
DOI: DOI:10.1038/415321a   (Journal Full-text)

Neurotransmitters are released by synaptic vesicle fusion at the active zone. The active zone of a synapse mediates Ca2+-triggered neurotransmitter release, and integrates presynaptic signals in regulating this release. Much is known about the structure of active zones and synaptic vesicles, but the functional relation between their components is poorly understood. Here we show that RIM1alpha, an active zone protein that was identified as a putative effector for the synaptic vesicle protein Rab3A, interacts with several active zone molecules, including Munc13-1 (ref. 6) and alpha-liprins, to form a protein scaffold in the presynaptic nerve terminal. Abolishing the expression of RIM1alpha in mice shows that RIM1alpha is essential for maintaining normal probability of neurotransmitter release, and for regulating release during short-term synaptic plasticity. These data indicate that RIM1alpha has a central function in integrating active zone proteins and synaptic vesicles into a molecular scaffold that controls neurotransmitter release.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Ppfia3Ratneurotransmitter secretion  IMP  RGD 
Ppfia3Ratregulation of short-term neuronal synaptic plasticity  IMP  RGD 

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Ppfia3Ratprotein binding  IPIRGD:620000 RGD 
Ppfia3Ratprotein binding  IPIRGD:620001 RGD 
Rims1Ratprotein binding  IPIRGD:620054 RGD 
Rims2Ratprotein binding  IPIRGD:620054 RGD 


Genes (Rattus norvegicus)
Ppfia3  (PTPRF interacting protein alpha 3) Rims1  (regulating synaptic membrane exocytosis 1) Rims2  (regulating synaptic membrane exocytosis 2)

Gene Rims1 regulating synaptic membrane exocytosis 1 Mus musculus
Gene Ppfia4 PTPRF interacting protein alpha 4 Rattus norvegicus