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Gene: Ppfia4 (PTPRF interacting protein alpha 4) Rattus norvegicus
Analyze
Symbol:
Ppfia4
Name:
PTPRF interacting protein alpha 4
RGD ID:
620055
Description:
Predicted to be involved in synapse organization. Predicted to localize to presynaptic active zone. Orthologous to human PPFIA4 (PTPRF interacting protein alpha 4); INTERACTS WITH 2,6-dinitrotoluene; acrylamide; ammonium chloride.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
hypothetical protein LOC685423; liprin-alpha-4; LOC685423; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4; protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4; PTPRF-interacting protein alpha-4
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PPFIA4 (PTPRF interacting protein alpha 4)
HGNC
EggNOG, Ensembl, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):
Ppfia4 (protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4)
HGNC
EggNOG, NCBI, OMA, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ppfia4 (PTPRF interacting protein alpha 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PPFIA4 (PTPRF interacting protein alpha 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PPFIA4 (PTPRF interacting protein alpha 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ppfia4 (PTPRF interacting protein alpha 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PPFIA4 (PTPRF interacting protein alpha 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
PPFIA4 (PTPRF interacting protein alpha 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Ppfia4 (PTPRF interacting protein alpha 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PPFIA2 (PTPRF interacting protein alpha 2)
HGNC
OrthoDB
Homo sapiens (human):
PPFIA1 (PTPRF interacting protein alpha 1)
HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
PPFIA4 (PTPRF interacting protein alpha 4)
Alliance
DIOPT (HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Mus musculus (house mouse):
Ppfia4 (protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4)
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
ppfia4 (protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4)
Alliance
DIOPT (Hieranoid|OMA|OrthoFinder|PANTHER|PhylomeDB)
Drosophila melanogaster (fruit fly):
Liprin-alpha
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Caenorhabditis elegans (roundworm):
syd-2
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 13 51,134,831 - 51,183,321 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 13 51,134,525 - 51,183,269 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 13 56,191,119 - 56,239,610 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 13 47,252,084 - 47,300,744 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 13 47,266,851 - 47,298,660 (-) NCBI Celera 13 46,081,944 - 46,130,233 (-) NCBI Celera Cytogenetic Map 13 q13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - CTD
1,2-dimethylhydrazine decreases expression ISO RGD:737079 6480464 1, 2-Dimethylhydrazine results in decreased expression of PPFIA4 mRNA CTD PMID:22206623 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:737079 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:737079 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:737079 6480464 Tetrachlorodibenzodioxin affects the expression of PPFIA4 mRNA CTD PMID:28922406 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of PPFIA4 mRNA CTD PMID:21346803 3,4-methylenedioxymethamphetamine increases expression ISO RGD:737079 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of PPFIA4 mRNA CTD PMID:26251327 4,4'-sulfonyldiphenol decreases expression ISO RGD:737078 6480464 bis4-hydroxyphenylsulfone results in decreased expression of PPFIA4 mRNA CTD PMID:27685785 4-nonylphenol multiple interactions ISO RGD:737078 6480464 [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of PPFIA4 mRNA CTD PMID:23626723 4-tert-Octylphenol multiple interactions ISO RGD:737078 6480464 [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of PPFIA4 mRNA CTD PMID:23626723 acrylamide affects expression EXP 6480464 Acrylamide affects the expression of PPFIA4 mRNA CTD PMID:28959563 acrylamide increases expression ISO RGD:737079 6480464 Acrylamide results in increased expression of PPFIA4 mRNA CTD PMID:30807115 aflatoxin B1 decreases methylation ISO RGD:737078 6480464 Aflatoxin B1 results in decreased methylation of PPFIA4 intron CTD PMID:30157460 aflatoxin B2 decreases methylation ISO RGD:737078 6480464 aflatoxin B2 results in decreased methylation of PPFIA4 intron CTD PMID:30157460 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PPFIA4 mRNA CTD PMID:16483693 arsane affects methylation ISO RGD:737078 6480464 Arsenic affects the methylation of PPFIA4 gene CTD PMID:25304211 arsane multiple interactions ISO RGD:737078 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of PPFIA4 mRNA CTD PMID:32525701 arsenic atom multiple interactions ISO RGD:737078 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of PPFIA4 mRNA CTD PMID:32525701 arsenic atom affects methylation ISO RGD:737078 6480464 Arsenic affects the methylation of PPFIA4 gene CTD PMID:25304211 atrazine increases expression ISO RGD:737078 6480464 Atrazine results in increased expression of PPFIA4 mRNA CTD PMID:22378314 benzo[a]pyrene decreases methylation ISO RGD:737078 6480464 Benzoapyrene results in decreased methylation of PPFIA4 5' UTR CTD PMID:27901495 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PPFIA4 mRNA CTD PMID:25181051 , PMID:30816183 butanal increases expression ISO RGD:737078 6480464 butyraldehyde results in increased expression of PPFIA4 mRNA CTD PMID:26079696 carbamazepine affects expression ISO RGD:737078 6480464 Carbamazepine affects the expression of PPFIA4 mRNA CTD PMID:25979313 carbon nanotube decreases expression ISO RGD:737079 6480464 Nanotubes, Carbon analog results in decreased expression of PPFIA4 mRNA CTD PMID:25620056 carbon nanotube increases expression ISO RGD:737079 6480464 Nanotubes more ... CTD PMID:25554681 chlordecone decreases expression ISO RGD:737079 6480464 Chlordecone results in decreased expression of PPFIA4 mRNA CTD PMID:29980752 cobalt atom multiple interactions ISO RGD:737078 6480464 [tungsten carbide binds to Cobalt] which results in increased expression of PPFIA4 mRNA CTD PMID:20105288 cobalt dichloride increases expression ISO RGD:737078 6480464 cobaltous chloride results in increased expression of PPFIA4 mRNA CTD PMID:20105288 dioxygen increases expression ISO RGD:737078 6480464 Oxygen deficiency results in increased expression of PPFIA4 mRNA CTD PMID:24236059 , PMID:26516004 dioxygen multiple interactions ISO RGD:737079 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PPFIA4 mRNA CTD PMID:30529165 dorsomorphin multiple interactions ISO RGD:737078 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 ethanol decreases expression ISO RGD:737078 6480464 Ethanol results in decreased expression of PPFIA4 protein CTD PMID:20621659 ethanol multiple interactions ISO RGD:737079 6480464 Ethanol affects the expression of and affects the splicing of PPFIA4 mRNA CTD PMID:30319688 ethanol multiple interactions ISO RGD:737078 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of PPFIA4 mRNA CTD PMID:23378141 fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of PPFIA4 mRNA CTD PMID:30307764 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of PPFIA4 mRNA CTD PMID:18035473 folic acid multiple interactions ISO RGD:737078 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of PPFIA4 mRNA CTD PMID:23378141 folic acid decreases expression ISO RGD:737079 6480464 Folic Acid results in decreased expression of PPFIA4 mRNA CTD PMID:25629700 gemcitabine increases expression ISO RGD:737078 6480464 gemcitabine results in increased expression of PPFIA4 mRNA CTD PMID:17039268 hypochlorous acid decreases expression ISO RGD:737079 6480464 Hypochlorous Acid results in decreased expression of PPFIA4 mRNA CTD PMID:19376150 lead(0) affects expression ISO RGD:737078 6480464 Lead affects the expression of PPFIA4 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:737078 6480464 Lead affects the expression of PPFIA4 mRNA CTD PMID:28903495 mercury dibromide decreases expression ISO RGD:737078 6480464 mercuric bromide results in decreased expression of PPFIA4 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:737078 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of PPFIA4 mRNA CTD PMID:27188386 methylmercury chloride decreases expression ISO RGD:737078 6480464 methylmercuric chloride results in decreased expression of PPFIA4 mRNA CTD PMID:23179753 , PMID:28001369 nickel atom decreases expression ISO RGD:737078 6480464 Nickel results in decreased expression of PPFIA4 mRNA CTD PMID:24768652 nickel dichloride increases expression ISO RGD:737078 6480464 nickel chloride results in increased expression of PPFIA4 mRNA CTD PMID:21455298 p-tert-Amylphenol multiple interactions ISO RGD:737078 6480464 [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of PPFIA4 mRNA CTD PMID:23626723 PCB138 multiple interactions ISO RGD:737079 6480464 [2 more ... CTD PMID:25510870 phenylmercury acetate decreases expression ISO RGD:737078 6480464 Phenylmercuric Acetate results in decreased expression of PPFIA4 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:737078 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of PPFIA4 mRNA CTD PMID:27188386 propanal increases expression ISO RGD:737078 6480464 propionaldehyde results in increased expression of PPFIA4 mRNA CTD PMID:26079696 SB 431542 multiple interactions ISO RGD:737078 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 silicon dioxide decreases expression ISO RGD:737078 6480464 Silicon Dioxide analog results in decreased expression of PPFIA4 mRNA CTD PMID:25895662 silicon dioxide increases expression ISO RGD:737078 6480464 Silicon Dioxide results in increased expression of PPFIA4 mRNA CTD PMID:25351596 sodium arsenate multiple interactions ISO RGD:737078 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of PPFIA4 mRNA CTD PMID:32525701 sodium arsenite decreases expression ISO RGD:737078 6480464 sodium arsenite results in decreased expression of PPFIA4 mRNA, sodium arsenite results in decreased expression of PPFIA4 protein CTD PMID:21925251 , PMID:29301061 sunitinib increases expression ISO RGD:737078 6480464 Sunitinib results in increased expression of PPFIA4 mRNA CTD PMID:31533062 thapsigargin decreases expression ISO RGD:737078 6480464 Thapsigargin results in decreased expression of PPFIA4 mRNA CTD PMID:22378314 thimerosal decreases expression ISO RGD:737078 6480464 Thimerosal results in decreased expression of PPFIA4 mRNA CTD PMID:27188386 triclosan decreases expression ISO RGD:737078 6480464 Triclosan results in decreased expression of PPFIA4 mRNA CTD PMID:30510588 troglitazone increases expression ISO RGD:737079 6480464 troglitazone results in increased expression of PPFIA4 mRNA CTD PMID:28973697 Tungsten carbide multiple interactions ISO RGD:737078 6480464 [tungsten carbide binds to Cobalt] which results in increased expression of PPFIA4 mRNA CTD PMID:20105288 Tungsten carbide increases expression ISO RGD:737078 6480464 tungsten carbide results in increased expression of PPFIA4 mRNA CTD PMID:20105288 tunicamycin decreases expression ISO RGD:737078 6480464 Tunicamycin results in decreased expression of PPFIA4 mRNA CTD PMID:22378314 valproic acid increases methylation ISO RGD:737078 6480464 Valproic Acid results in increased methylation of PPFIA4 gene CTD PMID:29154799 valproic acid multiple interactions ISO RGD:737078 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of PPFIA4 mRNA CTD PMID:27188386 vorinostat decreases expression ISO RGD:737078 6480464 vorinostat results in decreased expression of PPFIA4 mRNA CTD PMID:27188386
1,2-dimethylhydrazine (ISO) 2,2',4,4',5,5'-hexachlorobiphenyl (ISO) 2,2',5,5'-tetrachlorobiphenyl (ISO) 2,3,7,8-tetrachlorodibenzodioxine (ISO) 2,6-dinitrotoluene (EXP) 3,4-methylenedioxymethamphetamine (ISO) 4,4'-sulfonyldiphenol (ISO) 4-nonylphenol (ISO) 4-tert-Octylphenol (ISO) acrylamide (EXP,ISO) aflatoxin B1 (ISO) aflatoxin B2 (ISO) ammonium chloride (EXP) arsane (ISO) arsenic atom (ISO) atrazine (ISO) benzo[a]pyrene (ISO) bisphenol A (EXP) butanal (ISO)
References
Additional References at PubMed
Genomics
QTLs in Region (Rnor_6.0)
1354666 Bp244 Blood pressure QTL 244 4.9 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 1 107975663 Rat 1354666 Bp244 Blood pressure QTL 244 4.9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 1 107975663 Rat 1354666 Bp244 Blood pressure QTL 244 4.9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 1 107975663 Rat 1581554 Pur11 Proteinuria QTL 11 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 13 9016906 82995569 Rat 1581573 Uae36 Urinary albumin excretion QTL 36 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 13 9016906 82995569 Rat 1581570 Eae17 Experimental allergic encephalomyelitis QTL 17 4.1 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 13 12193394 108478121 Rat 9589141 Insul28 Insulin level QTL 28 10.82 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 13 14096330 59096330 Rat 7411662 Foco29 Food consumption QTL 29 20.8 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 13 14096330 59096330 Rat 2302275 Gluco37 Glucose level QTL 37 3.8 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 13 14441582 51577031 Rat 2317040 Aia21 Adjuvant induced arthritis QTL 21 2.75 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 13 14624631 59624631 Rat 2317046 Aia8 Adjuvant induced arthritis QTL 8 3.9700000286102295 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 13 14624631 59624631 Rat 631645 Bp121 Blood pressure QTL 121 3.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 19810814 64810814 Rat 9589164 Gluco66 Glucose level QTL 66 6.67 0.001 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 13 20052477 65052477 Rat 1331784 Bp222 Blood pressure QTL 222 2.944 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 21482481 58537177 Rat 7207885 Glom27 Glomerulus QTL 27 3.9 kidney glomerulus integrity trait (VT:0010546) kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139) 13 24502279 108770533 Rat 61391 Bp5 Blood pressure QTL 5 5.6 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 28008338 73008338 Rat 70170 Eae14 Experimental allergic encephalomyelitis QTL 14 0.0024 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 13 28584452 73584452 Rat 1558644 Cm45 Cardiac mass QTL 45 3.6 0.002 heart mass (VT:0007028) heart wet weight (CMO:0000069) 13 29076934 74076934 Rat 6893338 Cm76 Cardiac mass QTL 76 0 0.99 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 13 29076934 74076934 Rat 1354621 Rf47 Renal function QTL 47 3.7 kidney renin amount (VT:0010559) kidney renin level (CMO:0002166) 13 35301263 107975663 Rat 2301962 Cm72 Cardiac mass QTL 72 4.12 heart left ventricle mass (VT:0007031) heart left ventricle weight (CMO:0000776) 13 36147533 64868393 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 36147533 99968921 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 36147533 99968921 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 36147533 99968921 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533) 13 36147533 99968921 Rat 2303563 Bw89 Body weight QTL 89 6 body mass (VT:0001259) body weight (CMO:0000012) 13 37346348 82346348 Rat 61340 Bp25 Blood pressure QTL 25 4.2 0.004 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 39372927 84372927 Rat 10755495 Bp387 Blood pressure QTL 387 3.78 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 39501300 93652524 Rat 4889861 Pur29 Proteinuria QTL 29 13.8 0.005 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 13 42310744 86833540 Rat 1331750 Bp220 Blood pressure QTL 220 2.98 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 42310744 87310744 Rat 70220 Bp55 Blood pressure QTL 55 5.75 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) 13 42508345 87508345 Rat 61349 Bp31 Blood pressure QTL 31 5.75 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) 13 42508345 87508345 Rat 1549897 Stresp12 Stress response QTL 12 3.35 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) 13 43575717 88575717 Rat 619615 Bp80 Blood pressure QTL 80 0.0354 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 45676629 90676629 Rat 4145117 Mcs27 Mammary carcinoma susceptibility QTL 27 0.0001 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) 13 48776655 53264877 Rat 6893344 Cm79 Cardiac mass QTL 79 1.5 0.04 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 13 49058507 67207219 Rat 12879472 Bp399 Blood pressure QTL 399 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 50609228 53264877 Rat 12879441 Bp396 Blood pressure QTL 396 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 51080989 96080989 Rat