RGD Reference Report - A family of cAMP-binding proteins that directly activate Rap1. - Rat Genome Database

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A family of cAMP-binding proteins that directly activate Rap1.

Authors: Kawasaki, H  Springett, GM  Mochizuki, N  Toki, S  Nakaya, M  Matsuda, M  Housman, DE  Graybiel, AM 
Citation: Kawasaki H, etal., Science 1998 Dec 18;282(5397):2275-9.
RGD ID: 632397
Pubmed: PMID:9856955   (View Abstract at PubMed)

cAMP (3',5' cyclic adenosine monophosphate) is a second messenger that in eukaryotic cells induces physiological responses ranging from growth, differentiation, and gene expression to secretion and neurotransmission. Most of these effects have been attributed to the binding of cAMP to cAMP-dependent protein kinase A (PKA). Here, a family of cAMP-binding proteins that are differentially distributed in the mammalian brain and body organs and that exhibit both cAMP-binding and guanine nucleotide exchange factor (GEF) domains is reported. These cAMP-regulated GEFs (cAMP-GEFs) bind cAMP and selectively activate the Ras superfamily guanine nucleotide binding protein Rap1A in a cAMP-dependent but PKA-independent manner. Our findings suggest the need to reformulate concepts of cAMP-mediated signaling to include direct coupling to Ras superfamily signaling.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Rapgef4RatcAMP binding  IDA  RGD 
Rapgef4Ratguanyl-nucleotide exchange factor activity  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Rapgef4  (Rap guanine nucleotide exchange factor 4)

Objects referenced in this article
Gene RAPGEF3 Rap guanine nucleotide exchange factor 3 Homo sapiens
Gene RAPGEF4 Rap guanine nucleotide exchange factor 4 Homo sapiens
Gene Rapgef3 Rap guanine nucleotide exchange factor 3 Rattus norvegicus

Additional Information