Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: RAPGEF4 (Rap guanine nucleotide exchange factor 4) Homo sapiens
Analyze
Symbol: RAPGEF4
Name: Rap guanine nucleotide exchange factor 4
Description: Predicted to have Ras guanyl-nucleotide exchange factor activity and cAMP binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of insulin secretion. Predicted to localize to plasma membrane. Implicated in autistic disorder; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-hydroxypropanoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2; CAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; CGEF2; EPAC; EPAC 2; EPAC2; exchange factor directly activated by cAMP 2; exchange protein directly activated by cAMP 2; Nbla00496; putative protein product of Nbla00496; Rap guanine nucleotide exchange factor (GEF) 4; RAP guanine-nucleotide-exchange factor (GEF) 4
Orthologs:
Mus musculus (house mouse) : Rapgef4 (Rap guanine nucleotide exchange factor (GEF) 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rapgef4 (Rap guanine nucleotide exchange factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rapgef4 (Rap guanine nucleotide exchange factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Canis lupus familiaris (dog) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rapgef4 (Rap guanine nucleotide exchange factor 4)
Sus scrofa (pig) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Chlorocebus sabaeus (African green monkey) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Heterocephalus glaber (naked mole-rat) : Rapgef4 (Rap guanine nucleotide exchange factor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2172,735,274 - 173,052,893 (+)EnsemblGRCh38hg38GRCh38
GRCh382172,735,282 - 173,052,893 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372173,600,525 - 173,917,621 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362173,308,771 - 173,625,867 (+)NCBINCBI36hg18NCBI36
Build 342173,426,113 - 173,743,122NCBI
Celera2167,213,920 - 167,531,026 (+)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2165,478,909 - 165,797,009 (+)NCBIHuRef
CHM1_12173,607,657 - 173,924,727 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on RAPGEF4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351048
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.