RGD Reference Report - Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. - Rat Genome Database

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Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins.

Authors: Ray, S  Britschgi, M  Herbert, C  Takeda-Uchimura, Y  Boxer, A  Blennow, K  Friedman, LF  Galasko, DR  Jutel, M  Karydas, A  Kaye, JA  Leszek, J  Miller, BL  Minthon, L  Quinn, JF  Rabinovici, GD  Robinson, WH  Sabbagh, MN  So, YT  Sparks, DL  Tabaton, M  Tinklenberg, J  Yesavage, JA  Tibshirani, R  Wyss-Coray, T 
Citation: Ray S, etal., Nat Med. 2007 Nov;13(11):1359-62. Epub 2007 Oct 14.
RGD ID: 5686815
Pubmed: PMID:17934472   (View Abstract at PubMed)
DOI: DOI:10.1038/nm1653   (Journal Full-text)

A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL3HumanAlzheimer's disease  IEP protein:decreased expression:plasmaRGD 
Il3RatAlzheimer's disease  ISOIL3 (Homo sapiens)protein:decreased expression:plasmaRGD 
Il3MouseAlzheimer's disease  ISOIL3 (Homo sapiens)protein:decreased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il3  (interleukin 3)

Genes (Mus musculus)
Il3  (interleukin 3)

Genes (Homo sapiens)
IL3  (interleukin 3)


Additional Information