RGD Reference Report - Increased endothelial gene expression of angiotensin AT1A receptor in cyclosporine induced hypertensive rats. - Rat Genome Database

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Increased endothelial gene expression of angiotensin AT1A receptor in cyclosporine induced hypertensive rats.

Authors: Iwai, J  Kanayama, Y  Inoue, NN  Okamura, M  Takeda, T 
Citation: Iwai J, etal., Eur J Pharmacol. 1993 Dec 1;248(4):341-4.
RGD ID: 5147456
Pubmed: PMID:8181542   (View Abstract at PubMed)

We examined the gene expression of angiotensin AT1A receptors in aortic endothelial cells of cyclosporine induced hypertensive rats using reverse transcribed polymerase chain reaction method. The gene expression of angiotensin AT1A receptors in aortic endothelial cells of cyclosporine induced hypertensive rats showed a two-fold increase when compared with that in normotensive control rats. These results raise a possibility that the up-regulation of endothelial angiotensin AT1A receptors participates in the pathogenesis of cyclosporine induced hypertension.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
AGTR1Humanhypertension  ISOAgtr1a (Rattus norvegicus)mRNA:increased expression:aortic endothelial cell RGD 
Agtr1aRathypertension  IEP mRNA:increased expression:aortic endothelial cell RGD 
Agtr1aMousehypertension  ISOAgtr1a (Rattus norvegicus)mRNA:increased expression:aortic endothelial cell RGD 


Genes (Rattus norvegicus)
Agtr1a  (angiotensin II receptor, type 1a)

Genes (Mus musculus)
Agtr1a  (angiotensin II receptor, type 1a)

Genes (Homo sapiens)
AGTR1  (angiotensin II receptor type 1)