RGD Reference Report - Overexpression of glucocorticoid receptor-beta in severe allergic rhinitis. - Rat Genome Database

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Overexpression of glucocorticoid receptor-beta in severe allergic rhinitis.

Authors: Ishida, A  Ohta, N  Koike, S  Aoyagi, M  Yamakawa, M 
Citation: Ishida A, etal., Auris Nasus Larynx. 2010 Oct;37(5):584-8. Epub 2010 Feb 24.
RGD ID: 4892593
Pubmed: PMID:20185258   (View Abstract at PubMed)
DOI: DOI:10.1016/j.anl.2009.12.002   (Journal Full-text)

OBJECTIVE: To clarify the role of glucocorticoid receptor-beta in resistance to glucocorticoid therapy for allergic rhinitis, we studied 37 tissue samples from 20 patients with severe allergic rhinitis, and samples from age-matched controls. METHODS: Patients were treated with intranasal fluticasone for 6 months and inferior turbinectomy was performed for patients with poor response to glucocorticoid treatment. The expression of glucocorticoid receptor-alpha (GR-alpha), glucocorticoid receptor-beta (GR-beta), and nuclear factor-kappaB (NF-kappaB) in nasal mucosa was studied immunohistochemically. RESULTS: GR-alpha and NF-kappaB were expressed to a similar extent in patients and controls, but GR-beta was expressed significantly more in patients, resulting in an increased GR-beta/GR-alpha ratio. CONCLUSION: Our findings suggest that GR-beta plays an important role in resistance to glucocorticoid therapy for allergic rhinitis, and its expression might be used as an additional parameter indicating steroid resistance in allergic rhinitis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NR3C1HumanPerennial Allergic Rhinitis  IEP protein:altered expression:nasal mucosaRGD 
Nr3c1RatPerennial Allergic Rhinitis  ISONR3C1 (Homo sapiens)protein:altered expression:nasal mucosaRGD 
Nr3c1MousePerennial Allergic Rhinitis  ISONR3C1 (Homo sapiens)protein:altered expression:nasal mucosaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Nr3c1  (nuclear receptor subfamily 3, group C, member 1)

Genes (Mus musculus)
Nr3c1  (nuclear receptor subfamily 3, group C, member 1)

Genes (Homo sapiens)
NR3C1  (nuclear receptor subfamily 3 group C member 1)


Additional Information