RGD Reference Report - Variation at HLA-DRB1 is associated with resistance to enteric fever. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Variation at HLA-DRB1 is associated with resistance to enteric fever.

Authors: Dunstan, Sarah J  Hue, Nguyen Thi  Han, Buhm  Li, Zheng  Tram, Trinh Thi Bich  Sim, Kar Seng  Parry, Christopher M  Chinh, Nguyen Tran  Vinh, Ha  Lan, Nguyen Phu Huong  Thieu, Nga Tran Vu  Vinh, Phat Voong  Koirala, Samir  Dongol, Sabina  Arjyal, Amit  Karkey, Abhilasha  Shilpakar, Olita  Dolecek, Christiane  Foo, Jia Nee  Phuong, Le Thi  Lanh, Mai Ngoc  Do, Tan  Aung, Tin  Hon, Do Nu  Teo, Yik Ying  Hibberd, Martin L  Anders, Katherine L  Okada, Yukinori  Raychaudhuri, Soumya  Simmons, Cameron P  Baker, Stephen  de Bakker, Paul I W  Basnyat, Buddha  Hien, Tran Tinh  Farrar, Jeremy J  Khor, Chiea Chuen 
Citation: Dunstan SJ, etal., Nat Genet. 2014 Dec;46(12):1333-6. doi: 10.1038/ng.3143. Epub 2014 Nov 10.
RGD ID: 36174025
Pubmed: PMID:25383971   (View Abstract at PubMed)
PMCID: PMC5099079   (View Article at PubMed Central)
DOI: DOI:10.1038/ng.3143   (Journal Full-text)

Enteric fever affects more than 25 million people annually and results from systemic infection with Salmonella enterica serovar Typhi or Paratyphi pathovars A, B or C(1). We conducted a genome-wide association study of 432 individuals with blood culture-confirmed enteric fever and 2,011 controls from Vietnam. We observed strong association at rs7765379 (odds ratio (OR) for the minor allele = 0.18, P = 4.5 × 10(-10)), a marker mapping to the HLA class II region, in proximity to HLA-DQB1 and HLA-DRB1. We replicated this association in 595 enteric fever cases and 386 controls from Nepal and also in a second independent collection of 151 cases and 668 controls from Vietnam. Imputation-based fine-mapping across the extended MHC region showed that the classical HLA-DRB1*04:05 allele (OR = 0.14, P = 2.60 × 10(-11)) could entirely explain the association at rs7765379, thus implicating HLA-DRB1 as a major contributor to resistance against enteric fever, presumably through antigen presentation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
H2-Eb1Mousetyphoid fever susceptibilityISOHLA-DRB1 (Homo sapiens)DNA:polymorphism: :HLA-DRB1*04:05 and rs7765379(human)RGD 
HLA-DRB1Humantyphoid fever susceptibilityIAGP DNA:polymorphism: :HLA-DRB1*04:05 and rs7765379(human)RGD 
RT1-Db1Rattyphoid fever susceptibilityISOHLA-DRB1 (Homo sapiens)DNA:polymorphism: :HLA-DRB1*04:05 and rs7765379(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information