RGD Reference Report - Reduced expression of adherens and gap junction proteins can have a fundamental role in the development of heart failure following cardiac hypertrophy in rats. - Rat Genome Database

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Reduced expression of adherens and gap junction proteins can have a fundamental role in the development of heart failure following cardiac hypertrophy in rats.

Authors: dos Santos, Daniele O  Blefari, Valdecir  Prado, Fernanda P  Silva, Carlos A  Fazan, Rubens  Salgado, Helio C  Ramos, Simone G  Prado, Cibele M 
Citation: dos Santos DO, etal., Exp Mol Pathol. 2016 Feb;100(1):167-76. doi: 10.1016/j.yexmp.2015.12.009. Epub 2015 Dec 17.
RGD ID: 264347602
Pubmed: PMID:26708424   (View Abstract at PubMed)
DOI: DOI:10.1016/j.yexmp.2015.12.009   (Journal Full-text)

Hypertension causes cardiac hypertrophy, cardiac dysfunction and heart failure (HF). The mechanisms implicated in the transition from compensated to decompensated cardiac hypertrophy are not fully understood. This study was aimed to investigate whether alterations in the expression of intercalated disk proteins could contribute to the transition of compensated cardiac hypertrophy to dilated heart development that culminates in HF. Male rats were submitted to abdominal aortic constriction and at 90 days post surgery (dps), three groups were observed: sham-operated animals (controls), animals with hypertrophic hearts (HH) and animals with hypertrophic + dilated hearts (HD). Blood pressure was evaluated. The hearts were collected and Western blot and immunofluorescence were performed to desmoglein-2, desmocollin-2, N-cadherin, plakoglobin, Bcatenin, and connexin-43. Cardiac systolic function was evaluated using the Vevo 2100 ultrasound system. Data were considered significant when p b 0.05. Seventy percent of the animals presented with HH and 30% were HD at 90 dps. The blood pressure increased in both groups. The amount of desmoglein-2 and desmocollin-2 expression was increased in both groups and no difference was observed in either group. The expression of N-cadherin, plakoglobin and B-catenin increased in the HHgroup and decreased in the HDgroup; and connexin-43 decreased only in theHDgroup. Therewas no difference between the ejection fraction and fractional shortening at 30 and 60 dps; however, they were decreased in the HD group at 90 dps. We found that while some proteins have increased expression accompanied by the increase in the cell volume associated with preserved systolic cardiac function in theHHgroup, these same proteins had decreased expression evenwithout significant reduction in the cell volume associated with decreased systolic cardiac function in HD group. The increased expression of desmoglein-2 and desmocollin-2 in both the HH and HD groups could work as a protective compensatory mechanism, helping tomaintain the dilated heart.We can hypothesize that inappropriate intercellular mechanical and electrical coupling associated with necrosis and/or apoptosis are important factors contributing to the transition to HF.



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Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
DSC2HumanCardiomegaly  ISODsc2 (Rattus norvegicus)protein:increased expression:heart (rat)RGD 
DSG2HumanCardiomegaly  ISODsg2 (Rattus norvegicus)protein:increased expression:heart (rat)RGD 
Dsc2MouseCardiomegaly  ISODsc2 (Rattus norvegicus)protein:increased expression:heart (rat)RGD 
Dsc2RatCardiomegaly  IEP protein:increased expression:heart (rat)RGD 
Dsg2MouseCardiomegaly  ISODsg2 (Rattus norvegicus)protein:increased expression:heart (rat)RGD 
Dsg2RatCardiomegaly  IEP protein:increased expression:heart (rat)RGD 
DSC2Humandilated cardiomyopathy  ISODsc2 (Rattus norvegicus)protein:increased expression:heart (rat)RGD 
DSG2Humandilated cardiomyopathy  ISODsg2 (Rattus norvegicus)protein:increased expression:heart (rat)RGD 
Dsc2Ratdilated cardiomyopathy  IEP protein:increased expression:heart (rat)RGD 
Dsc2Mousedilated cardiomyopathy  ISODsc2 (Rattus norvegicus)protein:increased expression:heart (rat)RGD 
Dsg2Ratdilated cardiomyopathy  IEP protein:increased expression:heart (rat)RGD 
Dsg2Mousedilated cardiomyopathy  ISODsg2 (Rattus norvegicus)protein:increased expression:heart (rat)RGD 
GJA1Humandilated cardiomyopathy  ISOGja1 (Rattus norvegicus)protein:decreased expression:heart (rat)RGD 
Gja1Ratdilated cardiomyopathy  IEP protein:decreased expression:heart (rat)RGD 
Gja1Mousedilated cardiomyopathy  ISOGja1 (Rattus norvegicus)protein:decreased expression:heart (rat)RGD 
1 to 15 of 15 rows


Genes (Rattus norvegicus)
Dsc2  (desmocollin 2) Dsg2  (desmoglein 2) Gja1  (gap junction protein, alpha 1)

Genes (Mus musculus)
Dsc2  (desmocollin 2) Dsg2  (desmoglein 2) Gja1  (gap junction protein, alpha 1)

Genes (Homo sapiens)
DSC2  (desmocollin 2) DSG2  (desmoglein 2) GJA1  (gap junction protein alpha 1)