RGD Reference Report - Differential expression of multiple somatostatin receptors in the rat cerebellum during development. - Rat Genome Database

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Differential expression of multiple somatostatin receptors in the rat cerebellum during development.

Authors: Viollet, C  Bodenant, C  Prunotto, C  Roosterman, D  Schaefer, J  Meyerhof, W  Epelbaum, J  Vaudry, H  Leroux, P 
Citation: Viollet C, etal., J Neurochem. 1997 Jun;68(6):2263-72.
RGD ID: 2325007
Pubmed: PMID:9166718   (View Abstract at PubMed)

The present study describes the expression pattern of somatostatin receptor genes during the development of rat cerebellum. Characterization of somatostatin receptors was carried out by binding studies using receptor subtype-selective ligands in the germinative epithelium and granule cell layer of the cerebellum from postnatal day 4 (P4) to P21 and in granule cell cultures. Quantitative reverse transcription-PCR carried out for the five receptor subtype mRNAs in cerebellar extracts showed that sst1 mRNAs are predominant at the end of gestation. A transient high expression of the sst2 gene was observed from P7 to P14. In parallel, high levels of binding sites sensitive to sst2 ligands were detected in the granule cell germinative epithelium and in granule cell cultures. sst3 mRNAs rapidly increased from P14 and became the predominant form at P21, but respective binding sites were not detected. Whereas sst4 mRNA levels were generally low, those of sst5 were nearly undetectable. Reverse transcription-PCR carried out in granule cell cultures revealed the relative abundance of sst mRNAs as follows: sst2 > sst1 > sst3 = sst4. sst5 mRNA was undetectable. The results show the expression of four somatostatin receptor genes, but only three receptors (sst1, sst4, and mainly sst2) were detected as binding sites during cerebellar development.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Sstr1Ratcerebellum development  IEP  RGD 
Sstr2Ratcerebellum development  IEP  RGD 
Sstr3Ratcerebellum development  IEP  RGD 


Genes (Rattus norvegicus)
Sstr1  (somatostatin receptor 1) Sstr2  (somatostatin receptor 2) Sstr3  (somatostatin receptor 3)