RGD Reference Report - Clinical significance of circulating hepatocyte growth factor, a new risk marker of carotid atherosclerosis in patients with Type 2 diabetes. - Rat Genome Database

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Clinical significance of circulating hepatocyte growth factor, a new risk marker of carotid atherosclerosis in patients with Type 2 diabetes.

Authors: Satani, K  Konya, H  Hamaguchi, T  Umehara, A  Katsuno, T  Ishikawa, T  Kohri, K  Hasegawa, Y  Suehiro, A  Kakishita, E  Namba, M 
Citation: Satani K, etal., Diabet Med. 2006 Jun;23(6):617-22.
RGD ID: 2313566
Pubmed: PMID:16759302   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1464-5491.2006.01849.x   (Journal Full-text)

AIMS: Recent studies have provided increasing evidence that hepatocyte growth factor (HGF) has a pathophysiological role in the development of diabetic complications. We set out to determine the relationship between serum HGF and risk factors for macroangiopathy including carotid atherosclerosis. Carotid atherosclerosis is an established and important risk factor for both cerebral and coronary artery diseases. METHODS: We studied 89 patients (48 males, 41 females, mean age 62.5 +/- 10.3 years) with Type 2 diabetes (DM). RESULTS: Serum levels of HGF correlated positively with both intimal-media thickness (IMT) (r = 0.24, P = 0.0248) and plaque score (r = 0.27, P = 0.0126). In multiple regression analysis, serum HGF was associated independently with IMT (standardized beta = 0.28, P = 0.0499). We also found that both IMT and plaque score were higher in patients with ischaemic heart disease (IHD) than in patients without IHD, and that plaque score in patients with lacunar infarcts was higher than in patients without lacunar infarcts. CONCLUSIONS: Serum HGF concentration may be a new marker of atherosclerotic complications in patients with Type 2 DM.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HGFHumancarotid artery disease  IEP associated with Diabetes Mellitus more ...RGD 
HgfRatcarotid artery disease  ISOHGF (Homo sapiens)associated with Diabetes Mellitus more ...RGD 
HgfMousecarotid artery disease  ISOHGF (Homo sapiens)associated with Diabetes Mellitus more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hgf  (hepatocyte growth factor)

Genes (Mus musculus)
Hgf  (hepatocyte growth factor)

Genes (Homo sapiens)
HGF  (hepatocyte growth factor)


Additional Information