RGD Reference Report - HLA class II polymorphism: protective or risk factors to breast cancer in Tunisia? - Rat Genome Database

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HLA class II polymorphism: protective or risk factors to breast cancer in Tunisia?

Authors: Baccar Harrath, A  Yacoubi Loueslati, B  Troudi, W  Hmida, S  Sedkaoui, S  Dridi, A  Jridi, A  Ben Ayed, F  Ben Rhomdhane, K  Ben Ammar Elgaaied, A 
Citation: Baccar Harrath A, etal., Pathol Oncol Res. 2006;12(2):79-81. Epub 2006 Jun 24.
RGD ID: 2306231
Pubmed: PMID:16799707   (View Abstract at PubMed)
DOI: DOI:PAOR.2006.12.2.0079   (Journal Full-text)

HLA system plays a key role in the tumor cells' escape from immune surveillance. Herein is the first report on the correlation of the susceptibility to breast cancer with HLA class II markers in Tunisia. Molecular typing of HLA-DRB1 and -DQB1 loci was undertaken for 70 Tunisian female patients. Comparison of allele and haplotype distribution between patients and 70 female control subjects reveals a negative association between HLADRB1* 07-DQB1*02 and the incidence of breast cancer in the Tunisian population.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
H2-Eb1Mousebreast cancer  ISOHLA-DRB1 (Homo sapiens) RGD 
HLA-DRB1Humanbreast cancer  IAGP  RGD 
RT1-Db1Ratbreast cancer  ISOHLA-DRB1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information