RGD Reference Report - Association between HLA Class II alleles with HPV mediated Cervical Cancer in Indian women. - Rat Genome Database

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Association between HLA Class II alleles with HPV mediated Cervical Cancer in Indian women.

Authors: Kohaar, I  Hussain, S  Thakur, N  Tiwari, P  Nasare, V  Batra, S  Singh, V  Bhambani, S  Das, BC  Sarkar, DP  Bharadwaj, M 
Citation: Kohaar I, etal., Hum Immunol. 2009 Jan 17.
RGD ID: 2306228
Pubmed: PMID:19272325   (View Abstract at PubMed)
DOI: DOI:10.1016/j.humimm.2009.01.003   (Journal Full-text)

We investigated the association of HLA II (DRB1 and DQB1) alleles with the susceptibility to HPV associated cervical precancer and cancer cases in a hospital based case-control study in North Indian population. A total of 202 subjects including 100 patients comprising 31 cervical precancer (CIN 2/3) and 69 invasive cervical cancer cases and 102 healthy controls were employed for the study. Both patients and controls were screened for Human Papillomavirus (HPV) infection by PCR based approach. Low resolution Polymerase Chain Reaction-Sequence Specific Priming (PCR-SSP) was employed to genotype HLA II (DRB1 and DQB1). Our results show that DRB1*15 allele/ DRB1*15-DQB1*06 haplotype may have predisposition for HPV infection ( P(c) < 0.05) or cervical cancer/ precancer ( P(c) < 0.05) development while DRB1*04 allele/ DRB1*04-DQB1*03 haplotype might exhibit susceptibility to cervical precancerous lesions ( P(c) < 0.05). DRB1*13 allele/ DRB1*13-DQB1*06 haplotype was found to be strongly protective against risk to HPV infection ( P(c) < 0.002) as well as cervical cancer ( P(c) 0.01). Therefore, we have demonstrated that HLA DR-DQ polymorphisms are involved in genetic susceptibility to cervical cancer or HPV infection in North Indian population.




  
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Term
Qualifier
Evidence
With
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Original Reference(s)
H2-Eb1Mousepapillomavirus infectious disease susceptibilityISOHLA-DRB1 (Homo sapiens) RGD 
HLA-DRB1Humanpapillomavirus infectious disease susceptibilityIAGP  RGD 
RT1-Db1Ratpapillomavirus infectious disease susceptibilityISOHLA-DRB1 (Homo sapiens) RGD 
H2-Eb1MouseUterine Cervical Neoplasms susceptibilityISOHLA-DRB1 (Homo sapiens) RGD 
HLA-DRB1HumanUterine Cervical Neoplasms susceptibilityIAGP  RGD 
RT1-Db1RatUterine Cervical Neoplasms susceptibilityISOHLA-DRB1 (Homo sapiens) RGD 


Genes (Rattus norvegicus)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)