RGD Reference Report - Subcellular localization of p27kip1 expression predicts poor prognosis in human ovarian cancer. - Rat Genome Database

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Subcellular localization of p27kip1 expression predicts poor prognosis in human ovarian cancer.

Authors: Rosen, DG  Yang, G  Cai, KQ  Bast RC, JR  Gershenson, DM  Silva, EG  Liu, J 
Citation: Rosen DG, etal., Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):632-7.
RGD ID: 2299089
Pubmed: PMID:15701850   (View Abstract at PubMed)

PURPOSE: The cyclin-dependent kinase inhibitor p27(kip1) regulates cellular progression from G(1) to S phase. Several studies have shown that loss of p27(kip1) protein expression is associated with disease progression in various malignancies. The purpose of this study was to evaluate the subcellular localization of this cyclin-dependent kinase inhibitor in a large cohort of primary ovarian carcinomas and compare the results with clinicopathologic variables and overall survival. EXPERIMENTAL DESIGN: Subcellular localization of p27(kip1) was first assessed by Western blotting in nuclear and cytoplasmic extract from 13 cases of ovarian carcinoma. Subcellular localization of the p27(kip1) protein was evaluated using tissue microarrays containing 421 cases of ovarian carcinoma. RESULTS: The presence of p27(kip1) in the cytoplasm regardless of the nuclear stain correlated strongly with late-stage disease (P < 0.03), extent of cytoreduction (P = 0.03), and shorter disease-specific survival (P < 0.0001). CONCLUSION: Cytoplasmic localization of p27(kip1) predicts poorer prognosis in ovarian carcinoma, particularly in late-stage disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CDKN1BHumanOvarian Neoplasms disease_progressionIEP  RGD 
Cdkn1bRatOvarian Neoplasms disease_progressionISOCDKN1B (Homo sapiens) RGD 
Cdkn1bMouseOvarian Neoplasms disease_progressionISOCDKN1B (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdkn1b  (cyclin-dependent kinase inhibitor 1B)

Genes (Mus musculus)
Cdkn1b  (cyclin dependent kinase inhibitor 1B)

Genes (Homo sapiens)
CDKN1B  (cyclin dependent kinase inhibitor 1B)


Additional Information