RGD Reference Report - Evidence for activation of nuclear factor kappaB in obstructive sleep apnea. - Rat Genome Database

RGD Reference Report - Evidence for activation of nuclear factor kappaB in obstructive sleep apnea. - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

General

Evidence for activation of nuclear factor kappaB in obstructive sleep apnea.
Authors:	Yamauchi, M Tamaki, S Tomoda, K Yoshikawa, M Fukuoka, A Makinodan, K Koyama, N Suzuki, T Kimura, H
Citation:	Yamauchi M, etal., Sleep Breath. 2006 Dec;10(4):189-93.
RGD ID:	2298862
Pubmed:	PMID:17013605 (View Abstract at PubMed)
DOI:	DOI:10.1007/s11325-006-0074-x (Journal Full-text)
Obstructive sleep apnea (OSA) is a risk factor for atherosclerosis, and atherosclerosis evolves from activation of the inflammatory cascade. We propose that activation of the nuclear factor kappaB (NF-kappaB), a key transcription factor in the inflammatory cascade, occurs in OSA. Nine age-matched, nonsmoking, and non-hypertensive men with OSA symptoms and seven similar healthy subjects were recruited for standard polysomnography followed by the collection of blood samples for monocyte nuclear p65 concentrations (OSA and healthy groups). In the OSA group, p65 and of monocyte production of tumor necrosis factor alpha (TNF-alpha) were measured at the same time and after the next night of continuous positive airway pressure (CPAP). p65 Concentrations in the OSA group were significantly higher than in the control group [median, 0.037 ng/microl (interquartile range, 0.034 to 0.051) vs 0.019 ng/microl (interquartile range, 0.013 to 0.032); p = 0.008], and in the OSA group were significantly correlated with apnea-hypopnea index and time spent below an oxygen saturation of 90% (r = 0.77 and 0.88, respectively) after adjustment for age and BMI. One night of CPAP resulted in a reduction in p65 [to 0.020 ng/mul (interquartile range, 0.010 to 0.036), p = 0.04] and levels of TNF-alpha production in cultured monocytes [16.26 (interquartile range, 7.75 to 24.85) to 7.59 ng/ml (interquartile range, 5.19 to 12.95), p = 0.01]. NF-kappaB activation occurs with sleep-disordered breathing. Such activation of NF-kappaB may contribute to the pathogenesis of atherosclerosis in OSA patients.

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
RELA	Human	obstructive sleep apnea		IEP		protein:increased expression:monocyte	RGD
Rela	Rat	obstructive sleep apnea		ISO	RELA (Homo sapiens)	protein:increased expression:monocyte	RGD
Rela	Mouse	obstructive sleep apnea		ISO	RELA (Homo sapiens)	protein:increased expression:monocyte	RGD

Genes (Rattus norvegicus)


Rela (RELA proto-oncogene, NF-kB subunit)

Genes (Mus musculus)


Rela (v-rel reticuloendotheliosis viral oncogene homolog A (avian))

Genes (Homo sapiens)


RELA (RELA proto-oncogene, NF-kB subunit)