RGD Reference Report - High telomerase RNA expression level is an adverse prognostic factor for favorable-histology Wilms' tumor. - Rat Genome Database

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High telomerase RNA expression level is an adverse prognostic factor for favorable-histology Wilms' tumor.

Authors: Dome, JS  Bockhold, CA  Li, SM  Baker, SD  Green, DM  Perlman, EJ  Hill, DA  Breslow, NE 
Citation: Dome JS, etal., J Clin Oncol. 2005 Dec 20;23(36):9138-45. Epub 2005 Sep 19.
RGD ID: 2291966
Pubmed: PMID:16172460   (View Abstract at PubMed)
DOI: DOI:10.1200/JCO.2005.00.562   (Journal Full-text)

PURPOSE: A primary objective of the fifth National Wilms Tumor Study (NWTS-5) was to identify prognostic indicators for patients with favorable-histology Wilms' tumor. The prognostic significance of telomerase expression level in primary tumor samples was assessed. PATIENTS AND METHODS: A case-cohort study was conducted involving 291 NWTS-5 registrants. Telomerase activity was measured using the telomeric repeat amplification protocol (TRAP). Expression levels of TERT mRNA (encoding the telomerase catalytic component) and TERC/hTR (the telomerase RNA template) were measured using quantitative real-time polymerase chain reaction. RESULTS: After excluding samples because of lack of viable tumor, RNA degradation, or insufficient clinical information, 244 patients remained for the final analysis (96 with relapse and 148 without relapse). Univariate analysis revealed a positive correlation between relative risk (RR) of relapse and levels of TERT mRNA and TERC expression. For each doubling in TERT mRNA and TERC level, the RR increased by a factor of 1.16 (95% CI, 1.04 to 1.29; P = .01) and 1.35 (95% CI, 1.11 to 1.64; P = .003), respectively. The one third of patients whose tumors had the highest TERC expression level had an RR of 2.06 (95% CI, 1.14 to 3.70; P = .02) compared with patients with the lowest level. TERC expression level remained a significant prognostic indicator in a multivariate analysis adjusting for TERT mRNA, tumor stage, and patient age. TRAP level did not correlate with RR of relapse. Telomerase expression levels were not predictive of overall survival. CONCLUSION: Telomerase RNA expression level may provide a clinically useful adjunct to the current risk classification schema for favorable-histology Wilms' tumor.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TERCHumannephroblastoma disease_progressionIEP  RGD 
TERTHumannephroblastoma disease_progressionIEP  RGD 
TercRatnephroblastoma disease_progressionISOTERC (Homo sapiens) RGD 
TercMousenephroblastoma disease_progressionISOTERC (Homo sapiens) RGD 
TertRatnephroblastoma disease_progressionISOTERT (Homo sapiens) RGD 
TertMousenephroblastoma disease_progressionISOTERT (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Terc  (telomerase RNA component)
Tert  (telomerase reverse transcriptase)

Genes (Mus musculus)
Terc  (telomerase RNA component)
Tert  (telomerase reverse transcriptase)

Genes (Homo sapiens)
TERC  (telomerase RNA component)
TERT  (telomerase reverse transcriptase)


Additional Information