RGD Reference Report - Neuregulin-1 attenuates neointimal formation following vascular injury and inhibits the proliferation of vascular smooth muscle cells. - Rat Genome Database

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Neuregulin-1 attenuates neointimal formation following vascular injury and inhibits the proliferation of vascular smooth muscle cells.

Authors: Clement, CM  Thomas, LK  Mou, Y  Croslan, DR  Gibbons, GH  Ford, BD 
Citation: Clement CM, etal., J Vasc Res. 2007;44(4):303-12. Epub 2007 Apr 16.
RGD ID: 2289992
Pubmed: PMID:17438359   (View Abstract at PubMed)
DOI: DOI:10.1159/000101776   (Journal Full-text)

Neuregulin-1 (NRG-1) is expressed in vascular endothelial cells, and its receptors are localized to the underlying smooth muscle cells. However, the role of NRG-1 in vascular function and injury is largely unknown. First, the expression of NRG-1 and its receptors (erbB receptors) was analyzed after balloon injury to the rat carotid artery. NRG-1 and erbB expression levels were low in uninjured vessels; however, NRG-1 and erbB4 were upregulated following injury. We then examined the effect of NRG-1 on neointimal formation following balloon injury. NRG-1 was administered by tail-vein injection prior to injury and every 2 days following injury. Two weeks after injury, NRG-1-treated animals demonstrated a 50% reduction in lesion size compared with controls receiving the vehicle. To examine possible mechanisms for NRG-1 action, we examined its effects on vascular smooth muscle cell (VSMC) function. Rat VSMC cultures were pretreated with NRG-1 for 24 h and then stimulated with platelet-derived growth factor. NRG-1 significantly decreased platelet-derived growth factor-stimulated VSMC proliferation and migration. These findings suggest that NRG-1 may be a novel therapeutic candidate for the treatment of restenosis and atherosclerosis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ERBB4HumanNeointima  ISOErbb4 (Rattus norvegicus) RGD 
Erbb4RatNeointima  IEP  RGD 
Erbb4MouseNeointima  ISOErbb4 (Rattus norvegicus) RGD 
NRG1HumanNeointima  ISONrg1 (Rattus norvegicus) RGD 
Nrg1RatNeointima  IEP  RGD 
Nrg1MouseNeointima  ISONrg1 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Erbb4  (erb-b2 receptor tyrosine kinase 4)
Nrg1  (neuregulin 1)

Genes (Mus musculus)
Erbb4  (erb-b2 receptor tyrosine kinase 4)
Nrg1  (neuregulin 1)

Genes (Homo sapiens)
ERBB4  (erb-b2 receptor tyrosine kinase 4)
NRG1  (neuregulin 1)


Additional Information