RGD Reference Report - Expression of toll-like receptor 9 in peripheral blood mononuclear cells from patients with different hepatitis B and C viral loads. - Rat Genome Database

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Expression of toll-like receptor 9 in peripheral blood mononuclear cells from patients with different hepatitis B and C viral loads.

Authors: Zhou, Jian  Huang, Yuancheng  Tian, Deying  Xu, Dong  Chen, Miao  Wu, Huiling 
Citation: Zhou J, etal., J Huazhong Univ Sci Technolog Med Sci. 2009 Jun;29(3):313-7. doi: 10.1007/s11596-009-0310-2. Epub 2009 Jun 10.
RGD ID: 18337470
Pubmed: PMID:19513613   (View Abstract at PubMed)
DOI: DOI:10.1007/s11596-009-0310-2   (Journal Full-text)

The aim of the present study was to investigate the expression of toll-like receptors (TLR) 9 in peripheral blood mononuclear cells (PBMC) of patients with chronic hepatitis B and C with different virus copies. The study group included 90 patients (60 with chronic hepatitis B, and 30 with chronic hepatitis C), and 20 healthy people served as control group. The protein and mRNA levels of TLR9 were detected by using flow cytometry and real-time PCR. The serum viral copies of HBV and HCV were measured in all patients, and the correlation between HBV-DNA copies or HCV-RNA copies and the TLR9 expression was analyzed. Our results demonstrated that HBV or HCV infection led to a decreased expression of TLR9 mRNA and protein compared to the control group (P<0.05). The TLR9 protein and mRNA levels were negatively correlated with serum viral copies of HBV and HCV (r=-0.632, r=-0.909, P<0.01). It was concluded that TLR9 mRNA and protein are down-regulated in PBMC of HBV-infected or HCV-infected patients, and they are negatively correlated with serum viral copies and play an important role in detecting viral replication of HBV and HCV.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TLR9HumanChronic Hepatitis B severityIEP mRNA and protein:decreased expression:peripheral blood mononuclear cell (human)RGD 
Tlr9RatChronic Hepatitis B severityISOTLR9 (Homo sapiens)mRNA and protein:decreased expression:peripheral blood mononuclear cell (human)RGD 
Tlr9MouseChronic Hepatitis B severityISOTLR9 (Homo sapiens)mRNA and protein:decreased expression:peripheral blood mononuclear cell (human)RGD 
TLR9HumanChronic Hepatitis C severityIEP mRNA and protein:decreased expression:peripheral blood mononuclear cell (human)RGD 
Tlr9RatChronic Hepatitis C severityISOTLR9 (Homo sapiens)mRNA and protein:decreased expression:peripheral blood mononuclear cell (human)RGD 
Tlr9MouseChronic Hepatitis C severityISOTLR9 (Homo sapiens)mRNA and protein:decreased expression:peripheral blood mononuclear cell (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr9  (toll-like receptor 9)

Genes (Mus musculus)
Tlr9  (toll-like receptor 9)

Genes (Homo sapiens)
TLR9  (toll like receptor 9)


Additional Information