RGD Reference Report - Endosomal toll-like receptor gene polymorphisms and susceptibility to HIV and HCV co-infection - Differential influence in individuals with distinct ethnic background.

General

Endosomal toll-like receptor gene polymorphisms and susceptibility to HIV and HCV co-infection - Differential influence in individuals with distinct ethnic background.
Authors:	Valverde-Villegas, Jacqueline M Dos Santos, Bruno Paiva de Medeiros, Rúbia Marília Mattevi, Vanessa Suñé Lazzaretti, Rosmeri Kuhmmer Sprinz, Eduardo Kuhmmer, Regina Chies, José Artur Bogo
Citation:	Valverde-Villegas JM, etal., Hum Immunol. 2017 Feb;78(2):221-226. doi: 10.1016/j.humimm.2017.01.001. Epub 2017 Jan 4.
RGD ID:	18337466
Pubmed:	PMID:28062211 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.humimm.2017.01.001 (Journal Full-text)
The genetic background of human populations can influence the susceptibility and outcome of infection diseases. Toll-like receptors (TLRs) have been previously associated with susceptibility to human immunodeficiency virus (HIV) infection, disease progression and hepatitis C, virus (HCV) co-infection in different populations, although mostly in Europeans. In this study, we investigated the genetic role of endosomal TLRs on susceptibility to HIV infection and HCV co-infection through the analysis of TLR7 rs179008, TLR8 rs3764880, TLR9 rs5743836 and TLR9 rs352140 polymorphisms in 789 Brazilian individuals (374 HIV+ and 415 HIV-), taking into account their ethnic background. Amongst the 357 HIV+ individuals with available data concerning HCV infection, 98 were positive. In European descendants, the TLR9 rs5743836 C carriers displayed a higher susceptibility to HIV infection [dominant, Odds Ratio (OR)=1.53; 95% CI: 1.05-2.23; P=0.027]. In African descendants, TLR9 rs5743836 CT genotype was associated with protection to HIV infection (codominant, OR=0.51; 95% CI: 0.30-0.87; P=0.013). Also, the TLR9 rs352140 AA variant genotype was associated with susceptibility to HIV+/HCV+ co-infection in African descendants (recessive, OR=2.92; 95% CI: 1.22-6.98, P=0.016). These results are discussed in the context of the different ethnic background of the studied individuals highlighting the influence of this genetic/ethnic background on the susceptibility to HIV infection and HIV/HCV co-infection in Brazilian individuals.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
hepatitis C	susceptibility	IAGP		18337466	associated with acquired immunodeficiency syndrome and DNA:SNP:exon: (rs352140) (human)	RGD
hepatitis C	susceptibility	ISO	TLR9 (Homo sapiens)	18337466; 18337466	associated with acquired immunodeficiency syndrome and DNA:SNP:exon: (rs352140) (human)	RGD

Objects Annotated

Genes (Rattus norvegicus)

Tlr9 (toll-like receptor 9)

Genes (Mus musculus)

Tlr9 (toll-like receptor 9)

Genes (Homo sapiens)

TLR9 (toll like receptor 9)

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Endosomal toll-like receptor gene polymorphisms and susceptibility to HIV and HCV co-infection - Differential influence in individuals with distinct ethnic background.