RGD Reference Report - Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. - Rat Genome Database

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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.

Authors: Kadowaki, T  Yamauchi, T  Kubota, N  Hara, K  Ueki, K  Tobe, K 
Citation: Kadowaki T, etal., J Clin Invest. 2006 Jul;116(7):1784-92.
RGD ID: 1642395
Pubmed: PMID:16823476   (View Abstract at PubMed)
PMCID: PMC1483172   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI29126   (Journal Full-text)

Adiponectin is an adipokine that is specifically and abundantly expressed in adipose tissue and directly sensitizes the body to insulin. Hypoadiponectinemia, caused by interactions of genetic factors such as SNPs in the Adiponectin gene and environmental factors causing obesity, appears to play an important causal role in insulin resistance, type 2 diabetes, and the metabolic syndrome, which are linked to obesity. The adiponectin receptors, AdipoR1 and AdipoR2, which mediate the antidiabetic metabolic actions of adiponectin, have been cloned and are downregulated in obesity-linked insulin resistance. Upregulation of adiponectin is a partial cause of the insulin-sensitizing and antidiabetic actions of thiazolidinediones. Therefore, adiponectin and adiponectin receptors represent potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance. This Review describes the pathophysiology of adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Objects Annotated

Genes (Rattus norvegicus)
Adipoq  (adiponectin, C1Q and collagen domain containing)
Adipor1  (adiponectin receptor 1)
Adipor2  (adiponectin receptor 2)

Genes (Mus musculus)
Adipoq  (adiponectin, C1Q and collagen domain containing)
Adipor1  (adiponectin receptor 1)
Adipor2  (adiponectin receptor 2)

Genes (Homo sapiens)
ADIPOQ  (adiponectin, C1Q and collagen domain containing)
ADIPOR1  (adiponectin receptor 1)
ADIPOR2  (adiponectin receptor 2)


Additional Information