RGD Reference Report - Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke. - Rat Genome Database

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Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke.

Authors: Frenkel, D  Huang, Z  Maron, R  Koldzic, DN  Moskowitz, MA  Weiner, HL 
Citation: Frenkel D, etal., J Neurol Sci. 2005 Jun 15;233(1-2):125-32.
RGD ID: 1598629
Pubmed: PMID:15894335   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jns.2005.03.022   (Journal Full-text)

Mucosal tolerance has been used successfully to treat animal models of autoimmune diseases and is being tested in human diseases. In this work we demonstrate the reduction of infarct size following mucosal tolerance by myelin oligodendrocyte glycoprotein (MOG) (35-55) peptide in mouse stroke model. Nasal MOG was most efficacious and reduced ischemic infarct size by 70% at 24 h as well as improving behavior score. Using immunohistological methods and IL-10 -/- mice, we demonstrate the importance of IL-10-producing CD4+ T cells in the reduction of the ischemic infarct volume following middle cerebral artery occlusion (MCAO). Furthermore, adoptive transfer of CD4+ T cells from nasally tolerized mice to untreated mice prior to MCAO surgery significantly decreased stroke size (p<0.001 vs. control), whereas CD4+ T cells from nasally tolerized IL-10-deficient mice had no significant effect. Based on these results, modulation of cerebral inflammation by mucosal tolerance to myelin antigens may have applicability both as prophylactic therapy and treatment following ischemia attacks.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL10HumanStroke severityISOIl10 (Mus musculus) RGD 
Il10RatStroke severityISOIl10 (Mus musculus) RGD 
Il10MouseStroke severityIAGP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information