RGD Reference Report - Enhanced expression of EGF receptor in a model of salt-sensitive hypertension. - Rat Genome Database

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Enhanced expression of EGF receptor in a model of salt-sensitive hypertension.

Authors: Ying, WZ  Sanders, PW 
Citation: Ying WZ and Sanders PW, Am J Physiol Renal Physiol. 2005 Aug;289(2):F314-21. Epub 2005 Apr 12.
RGD ID: 1580953
Pubmed: PMID:15827348   (View Abstract at PubMed)
DOI: DOI:10.1152/ajprenal.00003.2005   (Journal Full-text)

Chronic kidney disease in the Dahl/Rapp salt-sensitive (S) rat is related to an arteriolopathic process that occurs following the onset of hypertension and involves vascular smooth muscle cell (VSMC) hyperplasia and luminal constriction. Because previous studies have shown that activation of the epidermal growth factor receptor (EGFR) produces a mitogenic stimulus in VSMC and the EGFR participates integrally in the vasoconstrictor responses of renal arterioles, the present study analyzed the expression of EGFR in these animals. Compared with Sprague-Dawley (SD) rats, renal cortical expression of EGFR was increased in both prehypertensive and hypertensive S rats. Immunohistochemistry using a polyclonal antibody to EGFR demonstrated that EGFR expression was prominent in the renal vasculature, particularly in the media of afferent and efferent arterioles and the aorta of S rats. When examined, primary cultures of VSMC from S rats showed increased expression of EGFR, compared with VSMC from SD and Dahl/Rapp salt-resistant rats. Following addition of EGF, autophosphorylation of the EGFR was enhanced in cells from S rats, as was the downstream signaling events that included activation of p42/44 MAPK and Akt pathways. Thus in vivo and in vitro studies demonstrated augmented expression and functional activity of the EGFR in S rats.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
EGFRHumanhypertension  ISOEgfr (Rattus norvegicus)mRNA and protein:increased expression:renal cortexRGD 
EgfrRathypertension  IEP mRNA and protein:increased expression:renal cortexRGD 
EgfrMousehypertension  ISOEgfr (Rattus norvegicus)mRNA and protein:increased expression:renal cortexRGD 

Objects Annotated

Genes (Rattus norvegicus)
Egfr  (epidermal growth factor receptor)

Genes (Mus musculus)
Egfr  (epidermal growth factor receptor)

Genes (Homo sapiens)
EGFR  (epidermal growth factor receptor)


Additional Information