RGD Reference Report - Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells. - Rat Genome Database

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Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells.

Authors: Warnock, David G  Kusche-Vihrog, Kristina  Tarjus, Antoine  Sheng, Shaohu  Oberleithner, Hans  Kleyman, Thomas R  Jaisser, Frederic 
Citation: Warnock DG, etal., Nat Rev Nephrol. 2014 Mar;10(3):146-57. doi: 10.1038/nrneph.2013.275. Epub 2014 Jan 14.
RGD ID: 151356640
Pubmed: PMID:24419567   (View Abstract at PubMed)
PMCID: PMC4137491   (View Article at PubMed Central)
DOI: DOI:10.1038/nrneph.2013.275   (Journal Full-text)

Sodium transport in the distal nephron is mediated by epithelial sodium channel activity. Proteolytic processing of external domains and inhibition with increased sodium concentrations are important regulatory features of epithelial sodium channel complexes expressed in the distal nephron. By contrast, sodium channels expressed in the vascular system are activated by increased external sodium concentrations, which results in changes in the mechanical properties and function of endothelial cells. Mechanosensitivity and shear stress affect both epithelial and vascular sodium channel activity. Guyton's hypothesis stated that blood pressure control is critically dependent on vascular tone and fluid handling by the kidney. The synergistic effects, and complementary regulation, of the epithelial and vascular systems are consistent with the Guytonian model of volume and blood pressure regulation, and probably reflect sequential evolution of the two systems. The integration of vascular tone, renal perfusion and regulation of renal sodium reabsorption is the central underpinning of the Guytonian model. In this Review, we focus on the expression and regulation of sodium channels, and we outline the emerging evidence that describes the central role of amiloride-sensitive sodium channels in the efferent (vascular) and afferent (epithelial) arms of this homeostatic system.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Scnn1aRatcellular response to aldosterone involved_inNAS PMID:24419567ComplexPortal 
Scnn1bRatcellular response to aldosterone involved_inNAS PMID:24419567ComplexPortal 
Scnn1gRatcellular response to aldosterone involved_inNAS PMID:24419567ComplexPortal 
Scnn1aRatcellular response to vasopressin involved_inNAS PMID:24419567ComplexPortal 
Scnn1bRatcellular response to vasopressin involved_inNAS PMID:24419567ComplexPortal 
Scnn1gRatcellular response to vasopressin involved_inNAS PMID:24419567ComplexPortal 
Scnn1aRatregulation of blood pressure involved_inNAS PMID:24419567ComplexPortal 
Scnn1bRatregulation of blood pressure involved_inNAS PMID:24419567ComplexPortal 
Scnn1gRatregulation of blood pressure involved_inNAS PMID:24419567ComplexPortal 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Scnn1aRatplasma membrane part_ofNAS PMID:24419567ComplexPortal 
Scnn1bRatplasma membrane part_ofNAS PMID:24419567ComplexPortal 
Scnn1gRatplasma membrane part_ofNAS PMID:24419567ComplexPortal 

Objects Annotated

Genes (Rattus norvegicus)
Scnn1a  (sodium channel epithelial 1 subunit alpha)
Scnn1b  (sodium channel epithelial 1 subunit beta)
Scnn1g  (sodium channel epithelial 1 subunit gamma)


Additional Information