RGD Reference Report - Systemic activation of Toll-like receptor 2 suppresses mitochondrial respiration and exacerbates hypoxic-ischemic injury in the developing brain. - Rat Genome Database

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Systemic activation of Toll-like receptor 2 suppresses mitochondrial respiration and exacerbates hypoxic-ischemic injury in the developing brain.

Authors: Mottahedin, Amin  Svedin, Pernilla  Nair, Syam  Mohn, Carl-Johan  Wang, Xiaoyang  Hagberg, Henrik  Ek, Joakim  Mallard, Carina 
Citation: Mottahedin A, etal., J Cereb Blood Flow Metab. 2017 Apr;37(4):1192-1198. doi: 10.1177/0271678X17691292. Epub 2017 Jan 1.
RGD ID: 15090829
Pubmed: PMID:28139935   (View Abstract at PubMed)
PMCID: PMC5453473   (View Article at PubMed Central)
DOI: DOI:10.1177/0271678X17691292   (Journal Full-text)

Infection and inflammation are known risk factors for neonatal brain injury. Mycoplasma and Gram-positive bacteria, for which Toll-like receptor 2 (TLR2) plays a key role in recognition and inflammatory response, are among the most common pathogens in the perinatal period. Here, we report that systemic activation of TLR2 by Pam3CSK4 (P3C) increases neural tissue loss and demyelination induced by subsequent hypoxia-ischemia (HI) in neonatal mice. High-resolution respirometry of brain isolated mitochondria revealed that P3C suppresses ADP-induced oxidative phosphorylation, the main pathway of cellular energy production. The results suggest that infection and inflammation might contribute to HI-induced energy failure.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TLR2HumanBrain Hypoxia-Ischemia  ISOTlr2 (Mus musculus) RGD 
Tlr2RatBrain Hypoxia-Ischemia  ISOTlr2 (Mus musculus) RGD 
Tlr2MouseBrain Hypoxia-Ischemia  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr2  (toll-like receptor 2)

Genes (Mus musculus)
Tlr2  (toll-like receptor 2)

Genes (Homo sapiens)
TLR2  (toll like receptor 2)


Additional Information