RGD Reference Report - A clinical association between Toll-like receptor 2 Arg753Gln polymorphism with recurrent cystic echinococcosis in postsurgery patients: A case control study. - Rat Genome Database

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A clinical association between Toll-like receptor 2 Arg753Gln polymorphism with recurrent cystic echinococcosis in postsurgery patients: A case control study.

Authors: Moradkhani, Mohammad Ali  Spotin, Adel  Mahami-Oskouei, Mahmoud  Ahmadpour, Ehsan  Lotfinezhad, Mahsa  Noori, Jafar  Alizadeh, Zahra 
Citation: Moradkhani MA, etal., Comp Immunol Microbiol Infect Dis. 2019 Oct;66:101336. doi: 10.1016/j.cimid.2019.101336. Epub 2019 Jul 24.
RGD ID: 15090825
Pubmed: PMID:31437685   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cimid.2019.101336   (Journal Full-text)

Recurrence of hydatid cysts in cystectomy patients has dramatically remained a serious concern within the surgical community. Predisposing factors for recurrence of hydatid cysts remained to be identified. Toll-like receptor (TLR) plays a pivotal role in bridging between acquired and innate immunity in cystic echinococcosis (CE) infection. 117 CE patients including 66 acute hydatidosis (AH; primary infection) and 51 recurrent hydatidosis (RH; chronic infection), and 117 ethnically matched healthy control (HC) were investigated from endemic regions of Iran in the period of 2015-2018. CE patients were definitely confirmed using histopathological and immunological assays. Genotyping of TLR2 Arg753Gln was carried out by restriction fragment length polymorphism and sequencing. The homozygous mutant-type TLR2 Gln/Gln (A/A) was represented to be associated with the occurrence of RH (P = 0.04) and conferred a 9 fold risk for susceptibility, while the heterozygous mutant-type TLR2 Arg/Gln (G/A) indicated a tendency to be associated with the occurrence of RH (P = 0.07). There was no discrepancy in the frequency of TLR2 Arg753Gln haplotypes between AH patients and HC individuals (P = 0.09). The mutant allele A was observed to be a risk factor for susceptibility to RH patients. Our results point to a clinical association between TLR2 Arg753Gln haplotypes with RH in postoperative patients. It can be inferred that allele G may lead to protection against the CE, while mutant allele A may be a diagnostic hallmark in the screening of RH susceptibility. Nevertheless, further studies with a larger sample size of different ethnic populations are required to authenticate this association.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TLR2Humancystic echinococcosis disease_progressionIAGP DNA:mutation:cds:Arg753Gln(human)RGD 
Tlr2Ratcystic echinococcosis disease_progressionISOTLR2 (Homo sapiens)DNA:mutation:cds:Arg753Gln(human)RGD 
Tlr2Mousecystic echinococcosis disease_progressionISOTLR2 (Homo sapiens)DNA:mutation:cds:Arg753Gln(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr2  (toll-like receptor 2)

Genes (Mus musculus)
Tlr2  (toll-like receptor 2)

Genes (Homo sapiens)
TLR2  (toll like receptor 2)


Additional Information