RGD Reference Report - Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population. - Rat Genome Database

RGD Reference Report - Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population. - Rat Genome Database

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Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population.
Authors:	Cao, Yun Miao, Xiao-Ping Huang, Ma-Yan Deng, Ling Hu, Li-Fu Ernberg, Ingemar Zeng, Yi-Xin Lin, Dong-Xin Shao, Jian-Yong
Citation:	Cao Y, etal., BMC Cancer. 2006 Jun 26;6:167. doi: 10.1186/1471-2407-6-167.
RGD ID:	150573694
Pubmed:	PMID:16796765 (View Abstract at PubMed)
PMCID:	PMC1550725 (View Article at PubMed Central)
DOI:	DOI:10.1186/1471-2407-6-167 (Journal Full-text)
BACKGROUND: Nasopharyngeal carcinoma (NPC) is one of the most common cancers in southern China. In addition to environmental factors such as Epstein-Barr virus infection and diet, genetic susceptibility has been reported to play a key role in the development of this disease. The x-ray repair cross-complementing group 1 (XRCC1) gene is important in DNA base excision repair. We hypothesized that two common single nucleotide polymorphisms of XRCC1 (codons 194 Arg-->Trp and 399 Arg-->Gln) are related to the risk of NPC and interact with tobacco smoking. METHODS: We sought to determine whether these genetic variants of the XRCC1 gene were associated with the risk of NPC among the Cantonese population in a hospital-based case control study using polymerase chain reaction-restriction fragment length polymorphism analysis. We conducted this study in 462 NPC patients and 511 healthy controls. RESULTS: After adjustment for sex and age, we found a reduced risk of developing NPC in individuals with the Trp194Trp genotype (OR = 0.48; 95% CI, 0.27-0.86) and the Arg194Trp genotype (OR = 0.79; 95% CI, 0.60-1.05) compared with those with the Arg194Arg genotype. Compared with those with the Arg399Arg genotype, the risk for NPC was not significantly different in individuals with the Arg399Gln genotype (OR = 0.82; 95% CI, 0.62-1.08) and the Gln399Gln genotype (OR = 1.20; 95% CI, 0.69-2.06). Further analyses stratified by gender and smoking status revealed a significantly reduced risk of NPC among males (OR = 0.32; 95% CI, 0.14-0.70) and smokers (OR = 0.34; 95% CI, 0.14-0.82) carrying the XRCC1 194Trp/Trp genotype compared with those carrying the Arg/Arg genotype. No association was observed between Arg399Gln variant genotypes and the risk of NPC combined with smoking and gender. CONCLUSION: Our findings suggest that the XRCC1 Trp194Trp variant genotype is associated with a reduced risk of developing NPC in Cantonese population, particularly in males and smokers. Larger studies are needed to confirm our findings and unravel the underlying mechanisms.

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
XRCC1	Human	nasopharynx carcinoma	sexual_dimorphism	IAGP		DNA:missense mutation:cds: p.R194W (human)	RGD
Xrcc1	Rat	nasopharynx carcinoma	sexual_dimorphism	ISO	XRCC1 (Homo sapiens)	DNA:missense mutation:cds: p.R194W (human)	RGD
Xrcc1	Mouse	nasopharynx carcinoma	sexual_dimorphism	ISO	XRCC1 (Homo sapiens)	DNA:missense mutation:cds: p.R194W (human)	RGD

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
XRCC1	Human	Neoplasia of the nasopharynx	sexual_dimorphism	IAGP		DNA:missense mutation:cds: p.R194W (human)	RGD

Genes (Rattus norvegicus)


Xrcc1 (X-ray repair cross complementing 1)

Genes (Mus musculus)


Xrcc1 (X-ray repair complementing defective repair in Chinese hamster cells 1)

Genes (Homo sapiens)


XRCC1 (X-ray repair cross complementing 1)