RGD Reference Report - The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. - Rat Genome Database

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The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.

Authors: Aleyasin, Hossein  Rousseaux, Maxime W C  Phillips, Maryam  Kim, Raymond H  Bland, Ross J  Callaghan, Steve  Slack, Ruth S  During, Matthew J  Mak, Tak W  Park, David S 
Citation: Aleyasin H, etal., Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18748-53. doi: 10.1073/pnas.0709379104. Epub 2007 Nov 14.
RGD ID: 13462069
Pubmed: PMID:18003894   (View Abstract at PubMed)
PMCID: PMC2141848   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.0709379104   (Journal Full-text)

Recent evidence has indicated that common mechanisms play roles among multiple neurological diseases. However, the specifics of these pathways are not completely understood. Stroke is caused by the interruption of blood flow to the brain, and cumulative evidence supports the critical role of oxidative stress in the ensuing neuronal death process. DJ-1 (PARK7) has been identified as the gene linked to early-onset familial Parkinson's disease. Currently, our work also shows that DJ-1 is central to death in both in Vitro and in Vivo models of stroke. Loss of DJ-1 increases the sensitivity to excitotoxicity and ischemia, whereas expression of DJ-1 can reverse this sensitivity and indeed provide further protection. Importantly, DJ-1 expression decreases markers of oxidative stress after stroke insult in Vivo, suggesting that DJ-1 protects through alleviation of oxidative stress. Consistent with this finding, we demonstrate the essential role of the oxidation-sensitive cysteine-106 residue in the neuroprotective activity of DJ-1 after stroke. Our work provides an important example of how a gene seemingly specific for one disease, in this case Parkinson's disease, also appears to be central in other neuropathological conditions such as stroke. It also highlights the important commonalities among differing neuropathologies.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PARK7Humancerebral infarction treatmentIMP  RGD 
PARK7Humancerebral infarction  ISOPark7 (Mus musculus) RGD 
Park7Ratcerebral infarction treatmentISOPARK7 (Homo sapiens) RGD 
Park7Ratcerebral infarction  ISOPark7 (Mus musculus) RGD 
Park7Mousecerebral infarction treatmentISOPARK7 (Homo sapiens) RGD 
Park7Mousecerebral infarction  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Park7  (Parkinsonism associated deglycase)

Genes (Mus musculus)
Park7  (Parkinson disease (autosomal recessive, early onset) 7)

Genes (Homo sapiens)
PARK7  (Parkinsonism associated deglycase)


Additional Information