RGD Reference Report - Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. - Rat Genome Database

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Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

Authors: Groszer, M  Erickson, R  Scripture-Adams, DD  Lesche, R  Trumpp, A  Zack, JA  Kornblum, HI  Liu, X  Wu, H 
Citation: Groszer M, etal., Science 2001 Dec 7;294(5549):2186-9. Epub 2001 Nov 01.
RGD ID: 1302564
Pubmed: PMID:11691952   (View Abstract at PubMed)
DOI: DOI:10.1126/science.1065518   (Journal Full-text)

The mechanisms controlling neural stem cell proliferation are poorly understood. Here we demonstrate that the PTEN tumor suppressor plays an important role in regulating neural stem/progenitor cells in vivo and in vitro. Mice lacking PTEN exhibited enlarged, histoarchitecturally abnormal brains, which resulted from increased cell proliferation, decreased cell death, and enlarged cell size. Neurosphere cultures revealed a greater proliferation capacity for tripotent Pten-/- central nervous system stem/progenitor cells, which can be attributed, at least in part, to a shortened cell cycle. However, cell fate commitments of the progenitors were largely undisturbed. Our results suggest that PTEN negatively regulates neural stem cell proliferation.



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