RGD Reference Report - Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. - Rat Genome Database

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Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells.

Authors: Yin, Yuqin  Henzl, Michael T  Lorber, Barbara  Nakazawa, Toru  Thomas, Tommy T  Jiang, Fan  Langer, Robert  Benowitz, Larry I 
Citation: Yin Y, etal., Nat Neurosci. 2006 Jun;9(6):843-52. Epub 2006 May 14.
RGD ID: 12793002
Pubmed: PMID:16699509   (View Abstract at PubMed)
DOI: DOI:10.1038/nn1701   (Journal Full-text)

The optic nerve, like most mature CNS pathways, does not regenerate after injury. Through unknown mechanisms, however, macrophage activation in the eye stimulates retinal ganglion cells (RGCs) to regenerate long axons beyond the site of optic nerve injury. Here we identify the calcium (Ca(2+))-binding protein oncomodulin as a potent macrophage-derived growth factor for RGCs and other neurons. Oncomodulin binds to rat RGCs with high affinity in a cyclic AMP (cAMP)-dependent manner and stimulates more extensive outgrowth than other known trophic agents. Depletion of oncomodulin from macrophage-conditioned media (MCM) eliminates the axon-promoting activity of MCM. The effects of oncomodulin involve downstream signaling via Ca(2+)/calmodulin kinase and gene transcription. In vivo, oncomodulin released from microspheres promotes regeneration in the mature rat optic nerve. Oncomodulin also stimulates outgrowth from peripheral sensory neurons. Thus, oncomodulin is a new growth factor for neurons of the mature central and peripheral nervous systems.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
axon regeneration involved_inIDA 12793002PMID:16699509UniProt 
response to wounding involved_inIDA 12793002PMID:16699509CAFA 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
extracellular space located_inIDA 12793002PMID:16699509CAFA 
supramolecular fiber located_inIDA 12793002PMID:16699509CAFA 
vesicle located_inIDA 12793002PMID:16699509CAFA 

Objects Annotated

Genes (Rattus norvegicus)
Cntf  (ciliary neurotrophic factor)
Ocm  (oncomodulin)


Additional Information