RGD Reference Report - The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. - Rat Genome Database

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The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.

Authors: Hall, Aisling O'Hara  Beiting, Daniel P  Tato, Cristina  John, Beena  Oldenhove, Guillaume  Lombana, Claudia Gonzalez  Pritchard, Gretchen Harms  Silver, Jonathan S  Bouladoux, Nicolas  Stumhofer, Jason S  Harris, Tajie H  Grainger, John  Wojno, Elia D Tait  Wagage, Sagie  Roos, David S  Scott, Philip  Turka, Laurence A  Cherry, Sara  Reiner, Steven L  Cua, Daniel  Belkaid, Yasmine  Elloso, M Merle  Hunter, Christopher A 
Citation: Hall AO, etal.
RGD ID: 126790522
Pubmed: PMID:22981537   (View Abstract at PubMed)
PMCID: PMC3477519   (View Article at PubMed Central)
DOI: DOI:10.1016/j.immuni.2012.06.014   (Journal Full-text)

Interferon-γ (IFN-γ) promotes a population of T-bet(+) CXCR3(+) regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii, a similar population emerged that limited T cell responses and was dependent on IFN-γ in the periphery but on IL-27 at mucosal sites. Transfer of Treg cells ameliorated the infection-induced pathology observed in Il27(-/-) mice, and this was dependent on their ability to produce IL-10. Microarray analysis revealed that Treg cells exposed to either IFN-γ or IL-27 have distinct transcriptional profiles. Thus, IFN-γ and IL-27 have different roles in Treg cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control Th1 cell-mediated immunity at local sites of inflammation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL27Humantoxoplasmosis  ISOIl27 (Mus musculus) RGD 
Il27Rattoxoplasmosis  ISOIl27 (Mus musculus) RGD 
Il27Mousetoxoplasmosis  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information