RGD Reference Report - Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis. - Rat Genome Database

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Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis.

Authors: Park, Jeongho  DeLong, Jonathan H  Knox, James J  Konradt, Christoph  Wojno, Elia D Tait  Hunter, Christopher A 
Citation: Park J, etal., Infect Immun. 2019 Nov 18;87(12). pii: IAI.00455-19. doi: 10.1128/IAI.00455-19. Print 2019 Dec.
RGD ID: 126790501
Pubmed: PMID:31548322   (View Abstract at PubMed)
PMCID: PMC6867838   (View Article at PubMed Central)
DOI: DOI:10.1128/IAI.00455-19   (Journal Full-text)

Interleukin-27 (IL-27) is a heterodimeric cytokine composed of the subunits IL-27p28 and EBi3, and while the IL-27 heterodimer influences T cell activities, there is evidence that IL-27p28 can have EBi3-independent activities; however, their relevance to infection is unclear. Therefore, the studies presented here compared how IL-27p28 transgenics and IL-27p28-/- mice responded to the intracellular parasite Toxoplasma gondii While the loss of IL-27p28 and its overexpression both result in increased susceptibility to T. gondii, the basis for this phenotype reveals distinct roles for IL-27p28. As a component of IL-27, IL-27p28 is critical to limit infection-induced T cell-mediated pathology, whereas the ectopic expression of IL-27p28 reduced the effector T cell population and had a major inhibitory effect on parasite-specific antibody titers and a failure to control parasite replication in the central nervous system. Indeed, transfer of immune serum to infected IL-27p28 transgenics resulted in reduced parasite burden and pathology. Thus, IL-27p28, independent of its role as a component of IL-27, can act as a negative regulator of humoral and cellular responses during toxoplasmosis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL27Humantoxoplasmosis susceptibilityISOIl27 (Mus musculus) RGD 
Il27Rattoxoplasmosis susceptibilityISOIl27 (Mus musculus) RGD 
Il27Mousetoxoplasmosis susceptibilityIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information