RGD Reference Report - CASTORing New Light on Amino Acid Sensing. - Rat Genome Database

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CASTORing New Light on Amino Acid Sensing.

Authors: Hallett, JE  Manning, BD 
Citation: Hallett JE and Manning BD, Cell. 2016 Mar 24;165(1):15-7. doi: 10.1016/j.cell.2016.03.002.
RGD ID: 11535047
Pubmed: PMID:27015302   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cell.2016.03.002   (Journal Full-text)

The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood. In this issue of Cell, Chantranupong et al. identify CASTOR1 as a direct arginine sensor that acts through the GATOR2 complex to regulate mTORC1.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Objects Annotated

Genes (Rattus norvegicus)
Castor1  (cytosolic arginine sensor for mTORC1 subunit 1)
Castor2  (cytosolic arginine sensor for mTORC1 subunit 2)

Genes (Mus musculus)
Castor1  (cytosolic arginine sensor for mTORC1 subunit 1)
Castor2  (cytosolic arginine sensor for mTORC1 subunit 2)

Genes (Homo sapiens)
CASTOR1  (cytosolic arginine sensor for mTORC1 subunit 1)
CASTOR2  (cytosolic arginine sensor for mTORC1 subunit 2)


Additional Information