CASTOR2 (cytosolic arginine sensor for mTORC1 subunit 2) - Rat Genome Database

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Gene: CASTOR2 (cytosolic arginine sensor for mTORC1 subunit 2) Homo sapiens
Analyze
Symbol: CASTOR2
Name: cytosolic arginine sensor for mTORC1 subunit 2
RGD ID: 2306471
HGNC Page HGNC:37073
Description: Enables identical protein binding activity. Involved in negative regulation of TORC1 signaling. Located in cytosol. Colocalizes with GATOR2 complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cellular arginine sensor for mTORC1 protein 2; cytosolic arginine sensor for mTORC1 subunit 1; GATS protein like 2; GATS protein-like 1; GATS protein-like 2; GATS-like protein 1; GATS-like protein 2; GATSL1; GATSL2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: CASTOR3P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,964,705 - 75,031,528 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl774,964,705 - 75,031,528 (+)EnsemblGRCh38hg38GRCh38
GRCh37774,422,144 - 74,445,631 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36774,645,541 - 74,706,426 (-)NCBINCBI36Build 36hg18NCBI36
Celera794,555,567 - 94,604,910 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,091,388 - 70,108,013 (+)NCBIHuRef
CHM1_1774,524,234 - 74,590,948 (+)NCBICHM1_1
T2T-CHM13v2.0776,167,039 - 76,233,789 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2774,140,669 - 74,200,405 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IDA,IEA,TAS)
GATOR2 complex  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. CASTORing New Light on Amino Acid Sensing. Hallett JE and Manning BD, Cell. 2016 Mar 24;165(1):15-7. doi: 10.1016/j.cell.2016.03.002.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9847074   PMID:12477932   PMID:12853948   PMID:21873635   PMID:26186194   PMID:26496610   PMID:26972053   PMID:28514442   PMID:33961781   PMID:35831314   PMID:36215168  


Genomics

Comparative Map Data
CASTOR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,964,705 - 75,031,528 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl774,964,705 - 75,031,528 (+)EnsemblGRCh38hg38GRCh38
GRCh37774,422,144 - 74,445,631 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36774,645,541 - 74,706,426 (-)NCBINCBI36Build 36hg18NCBI36
Celera794,555,567 - 94,604,910 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,091,388 - 70,108,013 (+)NCBIHuRef
CHM1_1774,524,234 - 74,590,948 (+)NCBICHM1_1
T2T-CHM13v2.0776,167,039 - 76,233,789 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2774,140,669 - 74,200,405 (-)NCBI
Castor2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,128,587 - 134,170,621 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,128,550 - 134,173,182 (+)EnsemblGRCm39 Ensembl
GRCm385134,099,748 - 134,141,782 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,099,711 - 134,144,343 (+)EnsemblGRCm38mm10GRCm38
MGSCv375134,575,618 - 134,617,652 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,384,375 - 134,426,409 (+)NCBIMGSCv36mm8
Celera5131,099,170 - 131,144,378 (+)NCBICelera
Cytogenetic Map5G2NCBI
Castor2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21222,577,504 - 22,620,182 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,577,512 - 22,620,182 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,718,358 - 23,761,287 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01224,329,459 - 24,372,393 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01223,395,063 - 23,438,110 (-)NCBIRnor_WKY
Rnor_6.01225,595,800 - 25,638,806 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,601,404 - 25,638,797 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,605,972 - 27,646,215 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,733,974 - 23,773,875 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,600,394 - 23,637,029 (-)NCBI
Celera1224,336,798 - 24,379,650 (-)NCBICelera
Cytogenetic Map12q12NCBI
Castor2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545613,242,401 - 13,282,469 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545613,242,401 - 13,282,469 (+)NCBIChiLan1.0ChiLan1.0
CASTOR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan17138,178,467 - 138,249,188 (+)NCBINHGRI_mPanPan1
PanPan1.1782,061,743 - 82,102,776 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl782,068,521 - 82,075,387 (-)Ensemblpanpan1.1panPan2
CASTOR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.165,565,723 - 5,602,799 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl65,548,758 - 5,598,582 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,250,167 - 7,304,365 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.065,364,915 - 5,419,601 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.165,290,447 - 5,344,659 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.065,304,003 - 5,358,215 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.065,466,510 - 5,520,788 (+)NCBIUU_Cfam_GSD_1.0
Castor2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344130,327,282 - 130,340,727 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365433,692,040 - 3,709,653 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365433,692,040 - 3,709,658 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASTOR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,956,300 - 12,039,978 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,956,289 - 12,039,913 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2311,676,540 - 11,759,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASTOR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,137,339 - 8,205,551 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,137,564 - 8,198,674 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660708,406,703 - 8,475,063 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Castor2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474013,324,809 - 13,360,179 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474013,324,798 - 13,363,640 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CASTOR2
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q11.22-21.11(chr7:71225344-81735657)x1 copy number loss See cases [RCV000050709] Chr7:71225344..81735657 [GRCh38]
Chr7:70690330..81364973 [GRCh37]
Chr7:70328266..81202909 [NCBI36]
Chr7:7q11.22-21.11		 pathogenic
GRCh38/hg38 7q11.21-21.11(chr7:64560824-79186156)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052318]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052318]|See cases [RCV000052318] Chr7:64560824..79186156 [GRCh38]
Chr7:64021202..78815472 [GRCh37]
Chr7:63658637..78653408 [NCBI36]
Chr7:7q11.21-21.11		 pathogenic
GRCh38/hg38 7q11.22-11.23(chr7:72649515-75361855)x3 copy number gain See cases [RCV000051965] Chr7:72649515..75361855 [GRCh38]
Chr7:72196405..74991125 [GRCh37]
Chr7:71752436..74829061 [NCBI36]
Chr7:7q11.22-11.23		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q11.22-11.23(chr7:69382353-77823832)x1 copy number loss See cases [RCV000054111] Chr7:69382353..77823832 [GRCh38]
Chr7:68847339..77453149 [GRCh37]
Chr7:68485275..77291085 [NCBI36]
Chr7:7q11.22-11.23		 pathogenic
GRCh38/hg38 7q11.23-21.11(chr7:73873420-83988860)x1 copy number loss See cases [RCV000054118] Chr7:73873420..83988860 [GRCh38]
Chr7:73992744..83618176 [GRCh37]
Chr7:72925686..83456112 [NCBI36]
Chr7:7q11.23-21.11		 pathogenic
GRCh38/hg38 7q11.23(chr7:74176025-75361855)x1 copy number loss See cases [RCV000054121] Chr7:74176025..75361855 [GRCh38]
Chr7:73992744..74991125 [GRCh37]
Chr7:73228291..74829061 [NCBI36]
Chr7:7q11.23		 pathogenic
GRCh38/hg38 7q11.23(chr7:74068087-75068321)x3 copy number gain See cases [RCV000141316] Chr7:74068087..75068321 [GRCh38]
Chr7:73482417..74481540 [GRCh37]
Chr7:73120353..74119476 [NCBI36]
Chr7:7q11.23		 likely benign
GRCh38/hg38 7q11.23(chr7:73352304-76722261)x1 copy number loss See cases [RCV000133638] Chr7:73352304..76722261 [GRCh38]
Chr7:72766313..76351578 [GRCh37]
Chr7:72404249..76189514 [NCBI36]
Chr7:7q11.23		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q11.23(chr7:73040501-75255046)x3 copy number gain See cases [RCV000135712] Chr7:73040501..75255046 [GRCh38]
Chr7:74285295..76351578 [GRCh37]
Chr7:73923231..76189514 [NCBI36]
Chr7:7q11.23		 uncertain significance
GRCh38/hg38 7q11.23(chr7:73040501-75255046)x3 copy number gain See cases [RCV000137731] Chr7:73040501..75255046 [GRCh38]
Chr7:72635638..74904285 [NCBI36]
Chr7:7q11.23		 pathogenic
GRCh38/hg38 7q11.23-21.11(chr7:74377395-82031742)x1 copy number loss See cases [RCV000142381] Chr7:74377395..82031742 [GRCh38]
Chr7:73992744..81661058 [GRCh37]
Chr7:73429661..81498994 [NCBI36]
Chr7:7q11.23-21.11		 pathogenic
GRCh38/hg38 7q11.21-11.23(chr7:62977085-75415352)x3 copy number gain See cases [RCV000142242] Chr7:62977085..75415352 [GRCh38]
Chr7:62437463..75044630 [GRCh37]
Chr7:62074898..74882566 [NCBI36]
Chr7:7q11.21-11.23		 pathogenic
GRCh38/hg38 7q11.21-11.23(chr7:62736364-75432710)x1 copy number loss See cases [RCV000142528] Chr7:62736364..75432710 [GRCh38]
Chr7:62196742..75061986 [GRCh37]
Chr7:61834177..74899922 [NCBI36]
Chr7:7q11.21-11.23		 pathogenic
GRCh38/hg38 7q11.23(chr7:73352304-75065728)x3 copy number gain See cases [RCV000142690] Chr7:73352304..75065728 [GRCh38]
Chr7:72766313..74481540 [GRCh37]
Chr7:72404249..74119476 [NCBI36]
Chr7:7q11.23		 pathogenic
GRCh38/hg38 7q11.22-21.11(chr7:72179092-79164071) copy number gain See cases [RCV000143454] Chr7:72179092..79164071 [GRCh38]
Chr7:71644077..78793387 [GRCh37]
Chr7:71282013..78631323 [NCBI36]
Chr7:7q11.22-21.11		 likely pathogenic
GRCh37/hg19 7q11.23(chr7:73591993-75914797)x1 copy number loss See cases [RCV000240532] Chr7:73591993..75914797 [GRCh37]
Chr7:7q11.23		 likely pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q11.23(chr7:72456604-76007380)x1 copy number loss See cases [RCV000510782] Chr7:72456604..76007380 [GRCh37]
Chr7:7q11.23		 pathogenic
Single allele deletion not provided [RCV000677988] Chr7:73591993..93683437 [GRCh37]
Chr7:7q11.23-21.3		 uncertain significance
GRCh37/hg19 7q11.23(chr7:72577021-74859638)x3 copy number gain not provided [RCV000682898] Chr7:72577021..74859638 [GRCh37]
Chr7:7q11.23		 pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q11.23(chr7:74772735-74837045)x0 copy number loss not provided [RCV000746814] Chr7:74772735..74837045 [GRCh37]
Chr7:7q11.23		 benign
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q11.23(chr7:72744494-76038818) copy number loss Williams syndrome [RCV000767638] Chr7:72744494..76038818 [GRCh37]
Chr7:7q11.23		 pathogenic
GRCh37/hg19 7q11.23(chr7:73799886-75388031)x1 copy number loss not provided [RCV000848421] Chr7:73799886..75388031 [GRCh37]
Chr7:7q11.23		 pathogenic
GRCh37/hg19 7q11.23(chr7:74852766-75180093)x1 copy number loss not provided [RCV001005970] Chr7:74852766..75180093 [GRCh37]
Chr7:7q11.23		 uncertain significance
GRCh37/hg19 7q11.23(chr7:72621722-76007380)x1 copy number loss not provided [RCV001005967] Chr7:72621722..76007380 [GRCh37]
Chr7:7q11.23		 pathogenic
GRCh37/hg19 7q11.23(chr7:72403117-76709600)x1 copy number loss not provided [RCV001258798] Chr7:72403117..76709600 [GRCh37]
Chr7:7q11.23		 pathogenic
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
Markers in Region
GDB:4585539  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37774,829,084 - 74,829,144UniSTSGRCh37
GRCh37774,417,269 - 74,417,329UniSTSGRCh37
Build 36774,055,205 - 74,055,265RGDNCBI36
Celera768,062,700 - 68,062,760RGD
Cytogenetic Map7q11.23UniSTS
HuRef770,086,513 - 70,086,573UniSTS
CRA_TCAGchr7v2774,162,148 - 74,162,208UniSTS
CRA_TCAGchr7v2773,750,333 - 73,750,393UniSTS
GDB:4585659  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37774,835,765 - 74,835,904UniSTSGRCh37
GRCh37774,410,520 - 74,410,659UniSTSGRCh37
Build 36774,048,456 - 74,048,595RGDNCBI36
Celera768,055,945 - 68,056,084RGD
Cytogenetic Map7q11.23UniSTS
HuRef770,079,733 - 70,079,872UniSTS
CRA_TCAGchr7v2774,168,829 - 74,168,968UniSTS
CRA_TCAGchr7v2773,743,584 - 73,743,723UniSTS
GDB:1234266  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37774,816,975 - 74,817,110UniSTSGRCh37
GRCh37774,429,298 - 74,429,433UniSTSGRCh37
Build 36774,067,234 - 74,067,369RGDNCBI36
Celera768,074,728 - 68,074,870RGD
Cytogenetic Map7q11.23UniSTS
HuRef770,098,401 - 70,098,536UniSTS
CRA_TCAGchr7v2774,150,039 - 74,150,174UniSTS
CRA_TCAGchr7v2773,762,362 - 73,762,497UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 46 11 18 15 55 16 754 725 391 19 89 108 4 693 3
Low 2223 2833 1357 325 1494 166 3551 1350 3264 152 1171 1342 166 1200 2086 1
Below cutoff 82 139 108 92 165 92 13 117 9 11 13 4 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001145064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC004166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC118138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC245150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK123110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR743064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN831814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN831815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR731193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000616305   ⟹   ENSP00000484732
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl774,964,705 - 75,031,528 (+)Ensembl
RefSeq Acc Id: ENST00000622472
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl775,007,888 - 75,021,943 (+)Ensembl
RefSeq Acc Id: NM_001145064   ⟹   NP_001138536
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38774,964,705 - 75,031,528 (+)NCBI
GRCh37774,807,605 - 74,867,341 (-)RGD
HuRef770,091,388 - 70,108,013 (+)NCBI
CHM1_1774,524,234 - 74,590,948 (+)NCBI
T2T-CHM13v2.0776,167,039 - 76,233,789 (+)NCBI
CRA_TCAGchr7v2774,140,669 - 74,200,405 (-)ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001138536 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A6NHX0 (Get FASTA)   NCBI Sequence Viewer  
  AAI47031 (Get FASTA)   NCBI Sequence Viewer  
  AAI47032 (Get FASTA)   NCBI Sequence Viewer  
  AAI50659 (Get FASTA)   NCBI Sequence Viewer  
  Q8N976 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001138536   ⟸   NM_001145064
- UniProtKB: B9EJH9 (UniProtKB/Swiss-Prot),   A6NHX0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000484732   ⟸   ENST00000616305
Protein Domains
ACT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6NHX0-F1-model_v2 AlphaFold A6NHX0 1-329 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:37073 AgrOrtholog
COSMIC CASTOR2 COSMIC
Ensembl Genes ENSG00000274070 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000484732 ENTREZGENE
  ENSP00000484732.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000616305 ENTREZGENE
  ENST00000616305.2 UniProtKB/Swiss-Prot
Gene3D-CATH VC0802-like UniProtKB/Swiss-Prot
GTEx ENSG00000274070 GTEx
HGNC ID HGNC:37073 ENTREZGENE
Human Proteome Map CASTOR2 Human Proteome Map
InterPro ACT-like_dom_sf UniProtKB/Swiss-Prot
  CASTOR1_N UniProtKB/Swiss-Prot
  CASTOR_ACT_dom UniProtKB/Swiss-Prot
  CASTOR_fam UniProtKB/Swiss-Prot
KEGG Report hsa:729438 UniProtKB/Swiss-Prot
NCBI Gene 729438 ENTREZGENE
OMIM 617033 OMIM
PANTHER CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE UniProtKB/Swiss-Prot
  CYTOSOLIC ARGININE SENSOR FOR MTORC1 SUBUNIT 2-RELATED UniProtKB/Swiss-Prot
  PRIMATE-EXPANDED PROTEIN FAMILY UniProtKB/Swiss-Prot
  PTHR12138:SF138 UniProtKB/Swiss-Prot
Pfam ACT_7 UniProtKB/Swiss-Prot
  Castor1_N UniProtKB/Swiss-Prot
PharmGKB PA164720237 PharmGKB
PRINTS F138DOMAIN UniProtKB/Swiss-Prot
  GATSLIKEFMLY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55021 UniProtKB/Swiss-Prot
UniProt A6NHX0 ENTREZGENE
  B9EJH9 ENTREZGENE
  CAST2_HUMAN UniProtKB/Swiss-Prot
  Q8N976 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A6NNH0 UniProtKB/Swiss-Prot
  B9EJH9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-28 CASTOR2  cytosolic arginine sensor for mTORC1 subunit 2  GATSL2  GATS protein like 2  Symbol and/or name change 5135510 APPROVED
2016-06-21 GATSL2  GATS protein like 2    GATS protein-like 2  Symbol and/or name change 5135510 APPROVED
2016-04-05 GATSL2  GATS protein-like 2  GATSL1  GATS protein-like 1  Data Merged 737654 PROVISIONAL