GWAS1020622_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1020622_H (phosphatidylcholine measurement QTL GWAS1020622 (human)) Homo sapiens

Symbol: GWAS1020622_H
Name: phosphatidylcholine measurement QTL GWAS1020622 (human)
RGD ID: 407371646
Trait: phosphatidylcholine measurement
LOD Score: Not Available
P Value: 5.0E-40
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381558,388,444 - 58,388,445RGD_MAPPER_PIPELINEGRCh38
GRCh371558,680,643 - 58,680,644RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1020622_HHumanphosphatidylcholine measurement  IAGPrs35853021405850206 GWAS_CATALOGPMID:34503513
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Position Markers

Peak: (rs35853021)
Human AssemblyChrPosition (strand)Source
GRCh381558,388,444 - 58,388,445RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407380360GWAS1029336_Holeoyl-arachidonoyl-glycerol (18:1/20:4) [2] measurement QTL GWAS1029336 (human)3e-14oleoyl-arachidonoyl-glycerol (18:1/20:4) [2] measurement155838844458388445Human
407380808GWAS1029784_H1-arachidonoyl-GPE (20:4n6) measurement QTL GWAS1029784 (human)8e-301-arachidonoyl-GPE (20:4n6) measurement155838844458388445Human
407214661GWAS863637_H3-hydroxybutyrate measurement QTL GWAS863637 (human)4e-10urine ketone body amount (VT:0010724)155838844458388445Human
407356931GWAS1005907_Hlevel of Sphingomyelin (d34:2) in blood serum QTL GWAS1005907 (human)0.0000002level of Sphingomyelin (d34:2) in blood serum155838844458388445Human
407379726GWAS1028702_Hphosphatidylethanolamine measurement QTL GWAS1028702 (human)4e-89phosphatidylethanolamine measurement155838844458388445Human
407243343GWAS892319_H1-stearoyl-GPE (18:0) measurement QTL GWAS892319 (human)1e-401-stearoyl-GPE (18:0) measurement155838844458388445Human
407376325GWAS1025301_Hphosphatidylethanolamine measurement QTL GWAS1025301 (human)3e-15phosphatidylethanolamine measurement155838844458388445Human
407386373GWAS1035349_Hphosphatidylcholine measurement QTL GWAS1035349 (human)1e-108phosphatidylcholine measurement155838844458388445Human
407353865GWAS1002841_Hcholesterol:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS1002841 (human)6e-48phosphatidylethanolamine measurementblood high density lipoprotein cholesterol level (CMO:0000052)155838844458388445Human
407380102GWAS1029078_H2-arachidonoyl-GPE (20:4) measurement QTL GWAS1029078 (human)4e-162-arachidonoyl-GPE (20:4) measurement155838844458388445Human
407196631GWAS845607_Hlactadherin measurement QTL GWAS845607 (human)1e-13phosphatidylethanolamine measurement155838844458388445Human
407380700GWAS1029676_H1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2) measurement QTL GWAS1029676 (human)1e-111-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2) measurement155838844458388445Human
2299958PRSTS330_HProstate tumor susceptibility QTL 330 (human)1.020.0151Prostate tumor susceptibility153479023060790230Human
407384592GWAS1033568_Hblood protein measurement QTL GWAS1033568 (human)1e-55blood protein measurementblood protein measurement (CMO:0000028)155838844458388445Human
407385365GWAS1034341_Hphosphatidylcholine measurement QTL GWAS1034341 (human)3e-117phosphatidylcholine measurement155838844458388445Human
407351002GWAS999978_HC-reactive protein measurement QTL GWAS999978 (human)1e-09C-reactive protein measurementblood C-reactive protein level (CMO:0003160)155838844458388445Human
407396821GWAS1045797_Hphosphatidylethanolamine measurement QTL GWAS1045797 (human)9e-10phosphatidylethanolamine measurement155838844458388445Human
407380074GWAS1029050_Hphosphatidylethanolamine measurement QTL GWAS1029050 (human)7e-16phosphatidylethanolamine measurement155838844458388445Human
407376874GWAS1025850_Hphosphatidylethanolamine measurement QTL GWAS1025850 (human)2e-105phosphatidylethanolamine measurement155838844458388445Human
407383018GWAS1031994_Hphosphatidylcholine measurement QTL GWAS1031994 (human)3e-74phosphatidylcholine measurement155838844458388445Human
407376878GWAS1025854_Hdiglyceride measurement QTL GWAS1025854 (human)4e-22diglyceride measurement155838844458388445Human
407259502GWAS908478_Hfree cholesterol to total lipids in small VLDL percentage QTL GWAS908478 (human)3e-13free cholesterol to total lipids in small VLDL percentage 155838844458388445Human
407358123GWAS1007099_H3-hydroxybutyrate measurement QTL GWAS1007099 (human)2e-12urine ketone body amount (VT:0010724)155838844458388445Human
407357227GWAS1006203_Hlevel of Triacylglycerol (53:3) in blood serum QTL GWAS1006203 (human)0.000001level of Triacylglycerol (53:3) in blood serum155838844458388445Human
1559354LDLPS4_HLow density lipoprotein particle size QTL 4 (human)2.20.019LDL particle size153479023060790230Human
407376869GWAS1025845_Hphosphatidylethanolamine measurement QTL GWAS1025845 (human)5e-29phosphatidylethanolamine measurement155838844458388445Human
407355817GWAS1004793_Hvery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio QTL GWAS1004793 (human)3e-19phosphatidylethanolamine measurementblood very low density lipoprotein cholesterol level (CMO:0000648)155838844458388445Human
407399590GWAS1048566_Hphosphatidylethanolamine measurement QTL GWAS1048566 (human)7e-12phosphatidylethanolamine measurement155838844458388445Human
407114550GWAS763526_Hfatty acid measurement QTL GWAS763526 (human)1e-10fatty acid measurement155838844458388445Human
407357877GWAS1006853_Htriglycerides:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS1006853 (human)5e-13triglycerides:total lipids ratio, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)155838844458388445Human
407384379GWAS1033355_Hlysophosphatidylethanolamine measurement QTL GWAS1033355 (human)7e-14lysophosphatidylethanolamine measurement155838844458388445Human
407357748GWAS1006724_Hfree cholesterol in small HDL measurement QTL GWAS1006724 (human)2e-10free cholesterol in small HDL measurement 155838844458388445Human
407386045GWAS1035021_Hphosphatidylcholine measurement QTL GWAS1035021 (human)7e-98phosphatidylcholine measurement155838844458388445Human
407371646GWAS1020622_Hphosphatidylcholine measurement QTL GWAS1020622 (human)5e-40phosphatidylcholine measurement155838844458388445Human
407116152GWAS765128_Homega-3 polyunsaturated fatty acid measurement QTL GWAS765128 (human)3e-11phosphatidylcholine measurement155838844458388445Human
407133178GWAS782154_Hlipid measurement QTL GWAS782154 (human)7e-76lipid measurementblood lipid measurement (CMO:0000050)155838844458388445Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS782154_H GCST001392 Lipid metabolism phenotypes 8,330 European ancestry individuals ? NR 7E-76 75.155 rs35853021 0.31 lipid measurement (EFO:0004529)
 PMID:22286219
GWAS845607_H GCST90248226 Lactadherin levels 10,708 European ancestry individuals T 0.36 1E-13 13 rs35853021 0.102 lactadherin measurement (EFO:0008203)
 PMID:34648354
GWAS863637_H GCST90269571 3-hydroxybutyrate levels (UKB data field 23474) 87,151 European ancestry individuals T 0.357299 4E-10 9.398 rs35853021 0.0308977 3-hydroxybutyrate measurement (EFO:0010982)
 PMID:36764567
GWAS892319_H GCST90199772 1-stearoyl-GPE (18:0) levels 8,270 European ancestry individuals T 0.349697 1E-40 40 rs35853021 0.209211 1-stearoyl-GPE (18:0) measurement (EFO:0800227)
 PMID:36635386
GWAS908478_H GCST90269699 Free cholesterol to total lipids in small VLDL percentage (UKB data field 23602) 88,329 European ancestry individuals T 0.357323 3E-13 12.523 rs35853021 0.0344895 free cholesterol to total lipids in small VLDL percentage (EFO:0022287)
 PMID:36764567
GWAS999978_H GCST90018950 C-reactive protein 353,466 European ancestry individuals, 83,025 East Asian ancestry individuals T NR 1E-9 9 rs35853021 0.0141 C-reactive protein measurement (EFO:0004458)
 PMID:34594039
GWAS1002841_H GCST90092893 Cholesterol to total lipids ratio in medium HDL 115,082 European ancestry individuals G 0.642368 6E-48 47.222 rs35853021 0.0596379 cholesterol:total lipids ratio (EFO:0020943)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS1004793_H GCST90302159 Phospholipids to total lipids ratio in very small VLDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals T 0.3815 3E-19 18.523 rs35853021 0.0367 very low density lipoprotein cholesterol measurement (EFO:0008317)
phospholipids:total lipids ratio (EFO:0020946)
 PMID:38448586
GWAS1005907_H GCST90244324 Sphingomyelin (d34:2) levels 2,624 European ancestry men T NR 2E-7 6.699 rs35853021 0.1489 PMID:36193934
GWAS1006203_H GCST90244534 Triacylglycerol (53:3) levels 4,642 European ancestry women T NR 0.000001 6 rs35853021 0.1078 PMID:36193934
GWAS1006724_H GCST90302083 Free cholesterol in small HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals T 0.3814 2E-10 9.699 rs35853021 0.0258 free cholesterol in small HDL measurement (EFO:0022270)
 PMID:38448586
GWAS1006853_H GCST90093015 Triglycerides to total lipids ratio in very large HDL 115,056 European ancestry individuals G 0.642361 5E-13 12.302 rs35853021 0.0292685 triglycerides:total lipids ratio (EFO:0020947)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS1007099_H GCST90092811 3-Hydroxybutyrate levels 113,594 European ancestry individuals G 0.642314 2E-12 11.699 rs35853021 0.0302559 3-hydroxybutyrate measurement (EFO:0010982)
 PMID:35213538
GWAS1020622_H GCST90060371 Phosphatidylcholine_37:6_[M+H]1+/Phosphatidylethanolamine_40:6_[M+H]1+/Phosphatidate_42:7_[M+NH4]1+ levels 13,814 British ancestry individuals T NR 5E-40 39.302 rs35853021 0.199199 phosphatidylcholine measurement (EFO:0010226)
 PMID:34503513
None Available GCST90060696 Phosphatidylcholine(33:2)_[M+H]1+/Phosphatidylethanolamine(36:2)_[M+H]1+/Phosphatidate(38:3)_[M+NH4]1+ levels 5,662 Pakistani ancestry individuals T NR 2E-12 11.699 rs35853021 0.0416 phosphatidylcholine measurement (EFO:0010226)
 PMID:34503513
None Available GCST90060692 Phosphatidylcholine(33:3)_[M+H]1+/Phosphatidylethanolamine(36:3)_[M+H]1+/Phosphatidate(38:4)_[M+NH4]1+ levels 5,662 Pakistani ancestry individuals C NR 2E-12 11.699 rs35853021 0.0414 phosphatidylcholine measurement (EFO:0010226)
 PMID:34503513
GWAS1025301_H GCST90060250 Phosphatidylethanolamine_34:1_[M-H]1- levels 13,814 British ancestry individuals T NR 3E-15 14.523 rs35853021 0.0836399 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:34503513
GWAS1025845_H GCST90060313 Phosphatidylethanolamine_38:5_[M-H]1- levels 13,814 British ancestry individuals T NR 5E-29 28.302 rs35853021 0.115374 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:34503513
GWAS1025850_H GCST90060310 Phosphatidylethanolamine_38:6_[M-H]1- levels 13,814 British ancestry individuals T NR 2E-105 104.699 rs35853021 0.262365 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:34503513
GWAS1025854_H GCST90060199 Diacylglycerol_38:6_[M+H-H2O]1+ levels 13,814 British ancestry individuals T NR 4E-22 21.398 rs35853021 0.100276 diglyceride measurement (EFO:0010223)
 PMID:34503513
None Available GCST90060200 Diacylglycerol_38:5_[M+H-H2O]1+ levels 13,814 British ancestry individuals T NR 2E-12 11.699 rs35853021 0.0606503 diacylglycerol 38:5 measurement (EFO:0020067)
 PMID:34503513
None Available GCST90060790 Phosphatidylcholine(37:6)_[M+H]1+/Phosphatidylethanolamine(40:6)_[M+H]1+/Phosphatidate(42:7)_[M+NH4]1+ levels 5,662 Pakistani ancestry individuals C NR 2E-12 11.699 rs35853021 0.0707 phosphatidylcholine measurement (EFO:0010226)
 PMID:34503513
None Available GCST90060738 Phosphatidylcholine(35:4)_[M+H]1+/Phosphatidylethanolamine(38:4)_[M+H]1+/Phosphatidate(40:5)_[M+NH4]1+ levels 5,662 Pakistani ancestry individuals G NR 2E-12 11.699 rs35853021 0.0662 phosphatidylcholine measurement (EFO:0010226)
 PMID:34503513
None Available GCST90060247 Phosphatidylethanolamine_34:2_[M-H]1- levels 13,814 British ancestry individuals T NR 6E-48 47.222 rs35853021 0.172849 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:34503513
GWAS1028702_H GCST90060272 Phosphatidylethanolamine_36:4_[M-H]1- levels 13,814 British ancestry individuals T NR 4E-89 88.398 rs35853021 0.237522 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:34503513
None Available GCST90060274 Phosphatidylethanolamine_36:3_[M-H]1- levels 13,814 British ancestry individuals T NR 3E-19 18.523 rs35853021 0.0960977 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:34503513
GWAS1029050_H GCST90060315 Phosphatidylethanolamine_38:4_[M-H]1- levels 13,814 British ancestry individuals T NR 7E-16 15.155 rs35853021 0.0693431 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:34503513
GWAS1029078_H GCST90244987 2-arachidonoyl-GPE (20:4) levels 14,296 European ancestry individuals T 0.3594 4E-16 15.398 rs35853021 0.08777216 2-arachidonoyl-GPE (20:4) measurement (EFO:0800260)
 PMID:36357675
GWAS1029336_H GCST90103107 Oleoyl-arachidonoyl-glycerol (18:1/20:4) [2] levels 8,809 European ancestry individuals T NR 3E-14 13.523 rs35853021 0.117 oleoyl-arachidonoyl-glycerol (18:1/20:4) [2] measurement (EFO:0800508)
 PMID:35050183
GWAS1029676_H GCST90244854 1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (p-16:0/18:2) levels 14,296 European ancestry individuals T 0.358 1E-11 11 rs35853021 0.072346166 1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2) measurement (EFO:0800422)
 PMID:36357675
GWAS1029784_H GCST90244891 1-arachidonoyl-GPE (20:4n6) levels 14,296 European ancestry individuals T 0.3584 8E-30 29.097 rs35853021 0.11855393 1-arachidonoyl-GPE (20:4n6) measurement (EFO:0800248)
 PMID:36357675
GWAS1031994_H GCST90060249 Phosphatidylcholine_31:2_[M+H]1+/Phosphatidylethanolamine_34:2_[M+H]1+/Phosphatidate_36:3_[M+NH4]1+ levels 13,814 British ancestry individuals T NR 3E-74 73.523 rs35853021 0.228534 phosphatidylcholine measurement (EFO:0010226)
 PMID:34503513
GWAS1033355_H GCST90060137 Lysophosphatidylethanolamine_16:0_[M-H]1- levels 13,814 British ancestry individuals T NR 7E-14 13.155 rs35853021 0.0834744 lysophosphatidylethanolamine measurement (EFO:0010225)
 PMID:34503513
GWAS1033568_H GCST90315252 KITLG/PLTP protein level ratio 43,509 European ancestry individuals ? NR 1E-55 55 rs35853021 0.111898 blood protein measurement (EFO:0007937)
 PMID:38412862
GWAS1034341_H GCST90060273 Phosphatidylcholine_33:4_[M+H]1+/Phosphatidylethanolamine_36:4_[M+H]1+/Phosphatidate_38:5_[M+NH4]1+ levels 13,814 British ancestry individuals T NR 3E-117 116.523 rs35853021 0.282351 phosphatidylcholine measurement (EFO:0010226)
 PMID:34503513
None Available GCST90060665 Phosphatidylethanolamine(34:2)_[M+H]1+ levels 5,662 Pakistani ancestry individuals T NR 2E-12 11.699 rs35853021 0.1139 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:34503513
None Available GCST90060689 Phosphatidylethanolamine(36:4)_[M-H]1- levels 5,662 Pakistani ancestry individuals C NR 2E-12 11.699 rs35853021 0.0651 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:34503513
None Available GCST90060319 Phosphatidylcholine_35:3_[M+H]1+/Phosphatidylethanolamine_38:3_[M+H]1+/Phosphatidate_40:4_[M+NH4]1+ levels 13,814 British ancestry individuals T NR 3E-11 10.523 rs35853021 0.0691858 phosphatidylcholine measurement (EFO:0010226)
 PMID:34503513
GWAS1035021_H GCST90060312 Phosphatidylcholine_35:6_[M+H]1+/Phosphatidylethanolamine_38:6_[M+H]1+/Phosphatidate_40:7_[M+NH4]1+ levels 13,814 British ancestry individuals T NR 7E-98 97.155 rs35853021 0.264751 phosphatidylcholine measurement (EFO:0010226)
 PMID:34503513
GWAS1035349_H GCST90060316 Phosphatidylcholine_35:4_[M+H]1+/Phosphatidylethanolamine_38:4_[M+H]1+/Phosphatidate_40:5_[M+NH4]1+ levels 13,814 British ancestry individuals T NR 1E-108 108 rs35853021 0.26446 phosphatidylcholine measurement (EFO:0010226)
 PMID:34503513
None Available GCST90060690 Phosphatidylethanolamine(36:4)_[M+H]1+ levels 5,662 Pakistani ancestry individuals A NR 2E-12 11.699 rs35853021 0.0381 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:34503513
GWAS1045797_H GCST90094888 Phosphatidylethanolamine (36:2) levels 650 Amish individuals T 0.35764 9E-10 9.046 rs35853021 0.3570088 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:35393526
None Available GCST90102106 Phosphatidylethanolamine (38:6) levels 650 Amish individuals T 0.35764 1E-13 13 rs35853021 0.42316476 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:35393526
None Available GCST90102099 Phosphatidylethanolamine (34:2) levels 650 Amish individuals T 0.35764 2E-12 11.699 rs35853021 0.40600026 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:35393526
GWAS1048566_H GCST90102101 Phosphatidylethanolamine (36:3) levels 650 Amish individuals T 0.35764 7E-12 11.155 rs35853021 0.40221164 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:35393526
None Available GCST90091514 Fasting omega-3 fatty acids null T 0.356604996 3E-11 10.523 rs35853021 0.142227 omega-3 polyunsaturated fatty acid measurement (EFO:0010119)
 PMID:34610981
None Available GCST90091589 Fasting saturated fatty acids null T 0.356080786 1E-10 10 rs35853021 0.137856 fatty acid measurement (EFO:0005110)
 PMID:34610981
Database Acc Id Source(s)
GWAS Catalog GCST90060371 GWAS Catalog

RGD Curation Notes
Note Type Note Reference