GWAS724698_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS724698_H (eosinophil count QTL GWAS724698 (human)) Homo sapiens

Symbol: GWAS724698_H
Name: eosinophil count QTL GWAS724698 (human)
RGD ID: 407075722
Trait: eosinophil quantity   (VT:0002602)    
Measurement Type: blood eosinophil count   (CMO:0000033)    
LOD Score: Not Available
P Value: 1.0E-15
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38123,520,972 - 23,520,973RGD_MAPPER_PIPELINEGRCh38
GRCh37123,847,464 - 23,847,465RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS724698_HHumanblood eosinophil count  IAGPrs2075995405850206Based on the EFO term IDGWAS_CATALOGPMID:34594039

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS724698_HHumaneosinophil quantity  IAGPrs2075995405850206Based on the EFO term IDGWAS_CATALOGPMID:34594039

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS724698_HHumaneosinophil count  IAGPrs2075995405850206 GWAS_CATALOGPMID:34594039
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Vertebrate Trait

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1348982E2F2E2F transcription factor 212350521223531233Human
153350276LOC126805658BRD4-independent group 4 enhancer GRCh37_chr1:23847293-2384849212352080123522000Human

Position Markers

Peak: (rs2075995)
Human AssemblyChrPosition (strand)Source
GRCh38123,520,972 - 23,520,973RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
407075722GWAS724698_Heosinophil count QTL GWAS724698 (human)1e-15eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12352097223520973Human
407046409GWAS695385_Hobsolete_red blood cell distribution width QTL GWAS695385 (human)2e-37obsolete_red blood cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)12352097223520973Human
407134222GWAS783198_Hobsolete_red blood cell distribution width QTL GWAS783198 (human)9e-41obsolete_red blood cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)12352097223520973Human
406979528GWAS628504_Hobsolete_red blood cell distribution width QTL GWAS628504 (human)2e-16obsolete_red blood cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)12352097223520973Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human
406963313GWAS612289_Heosinophil count QTL GWAS612289 (human)2e-22eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12352097223520973Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
407080402GWAS729378_Hobsolete_red blood cell distribution width QTL GWAS729378 (human)1e-24obsolete_red blood cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)12352097223520973Human
407085360GWAS734336_Heosinophil count QTL GWAS734336 (human)8e-11eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12352097223520973Human
406965946GWAS614922_Heosinophil count QTL GWAS614922 (human)1e-16eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12352097223520973Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
None Available GCST004621 Red cell distribution width 171,529 European ancestry individuals A 0.501 1E-24 24 rs2075995 0.03606049 Red cell distribution width (EFO:0009188)
 PMID:27863252
GWAS612289_H GCST007065 Eosinophil counts approximately 440,000 European ancestry individuals ? NR 2E-22 21.699 rs2075995 N/A eosinophil count (EFO:0004842)
 PMID:30595370
GWAS614922_H GCST90002381 Eosinophil counts 408,112 British individuals A 0.501124 1E-16 16 rs2075995 0.018312914 eosinophil count (EFO:0004842)
 PMID:32888494
GWAS724698_H GCST90018953 Eosinophil counts 349,856 European ancestry individuals, 93,063 East Asian ancestry individuals A NR 1E-15 15 rs2075995 0.0131 eosinophil count (EFO:0004842)
 PMID:34594039
GWAS734336_H GCST004606 Eosinophil counts 172,275 European ancestry individuals A 0.5011 8E-11 10.097 rs2075995 0.02306474 eosinophil count (EFO:0004842)
 PMID:27863252
None Available GCST007074 Red cell distribution width approximately 445,000 European ancestry individuals ? NR 2E-37 36.699 rs2075995 N/A Red cell distribution width (EFO:0009188)
 PMID:30595370
None Available GCST006804 Red cell distribution width 116,666 British ancestry individuals A 0.502 2E-16 15.699 rs2075995 0.0331247 Red cell distribution width (EFO:0009188)
 PMID:28957414
None Available GCST90002404 Red cell distribution width 408,112 British individuals A 0.501242 9E-41 40.046 rs2075995 0.029503876 Red cell distribution width (EFO:0009188)
 PMID:32888494
Database Acc Id Source(s)
GWAS Catalog GCST90018953 GWAS Catalog

RGD Curation Notes
Note Type Note Reference