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QTL Registration

General

QTL: GWAS641006_H (level of IgG receptor FcRn large subunit p51 in blood serum QTL GWAS641006 (human)) Homo sapiens

Symbol:

GWAS641006_H

Name:

level of IgG receptor FcRn large subunit p51 in blood serum QTL GWAS641006 (human)

RGD ID:

406992030

Trait:

level of IgG receptor FcRn large subunit p51 in blood serum

LOD Score:

Not Available

P Value:

2.0E-20

Variance:

Not Available

Position

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh38	19	49,524,783 - 49,524,784	RGD_MAPPER_PIPELINE	GRCh38
GRCh37	19	50,028,040 - 50,028,041	RGD_MAPPER_PIPELINE	GRCh37

Population Stats:

Not Available

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Experimental Factor Annotations Click to see Annotation Detail View

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
GWAS641006_H	Human	level of IgG receptor FcRn large subunit p51 in blood serum		IAGP	rs3810194	405850206		GWAS_CATALOG	PMID:35870639

References

References - curated

#	Reference Title	Reference Citation
1.	RGD GWAS Catalog Import Pipeline	RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region

The following Genes overlap with this region.

RGD ID	Symbol	Name	Chr	Start	Stop	Species
736100	FCGRT	Fc gamma receptor and transporter	19	49512661	49526428	Human

Position Markers

Peak: (rs3810194)

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	49,524,783 - 49,524,784	RGD_MAPPER_PIPELINE

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1559110	SCL22_H	Serum cholesterol level QTL 22 (human)	3.59	0.000241	Lipid level	LDL cholesterol	19	31907594	57907594	Human
406992030	GWAS641006_H	level of IgG receptor FcRn large subunit p51 in blood serum QTL GWAS641006 (human)		2e-20	level of IgG receptor FcRn large subunit p51 in blood serum		19	49524783	49524784	Human
1331657	COPD9_H	Chronic obstructive pulmonary disease QTL 9 (human)	1.94		Chronic airflow obstruction	post-bronchodilator FEV1	19	31021760	57021760	Human

Additional Information

GWAS QTLs Related by Peak Marker

Data has come from the GWAS Catalog		Download
The highlighted row represents the current QTL

QTL	GWAS Catalog Study	Disease Trait	Study Size	Risk Allele	Risk Allele Frequency	P Value	P Value MLOG	Peak Marker	Reported Odds Ratio or Beta-coefficient	Ontology Accession	PubMed
GWAS641006_H	GCST90235823	IgG receptor FcRn large subunit p51 level in Chronic kidney disease with hypertension and no diabetes (21708_149)	466 African American individuals	C	0.18	2E-20	19.699	rs3810194	0.75		PMID:35870639

External Database Links

Database	Acc Id	Source(s)
GWAS Catalog	GCST90235823	GWAS Catalog

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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QTL: GWAS641006_H (level of IgG receptor FcRn large subunit p51 in blood serum QTL GWAS641006 (human)) Homo sapiens