Iqcn (IQ motif containing N) - Rat Genome Database

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Gene: Iqcn (IQ motif containing N) Rattus norvegicus
Analyze
Symbol: Iqcn
Name: IQ motif containing N
RGD ID: 7549926
Description: Predicted to be involved in spermatid development. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in spermatogenic failure 78. Orthologous to human IQCN (IQ motif containing N); INTERACTS WITH bisphenol A; paraquat; 15-acetyldeoxynivalenol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IQ domain-containing protein N; LOC102547294; LOC306346; mucin-17-like; similar to KIAA1683; uncharacterized protein KIAA1683 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,750,492 - 18,766,184 (-)NCBIGRCr8
mRatBN7.21618,716,519 - 18,733,971 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,716,519 - 18,726,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,758,451 - 18,773,053 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,891,390 - 19,906,139 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,811,400 - 18,826,003 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,467,425 - 20,483,375 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01620,324,493 - 20,339,412 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,222,176 - 19,223,162 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1618,908,707 - 18,924,642 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IqcnRatMegalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1  ISOIQCN (Homo sapiens)8554872ClinVar Annotator: match by term: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1ClinVarPMID:28492532
IqcnRatspermatogenic failure 78  ISOIQCN (Homo sapiens)8554872ClinVar Annotator: match by term: Spermatogenic failure 78ClinVarPMID:25741868 and PMID:36321563
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IqcnRatspermatogenic failure 78  ISOIQCN (Homo sapiens)7240710 OMIM 

1 to 20 of 31 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IqcnRat15-acetyldeoxynivalenol increases expressionISOIQCN (Homo sapiens)648046415-acetyldeoxynivalenol results in increased expression of IQCN mRNACTDPMID:23792671
IqcnRat17beta-estradiol decreases expressionISOIQCN (Homo sapiens)6480464Estradiol results in decreased expression of IQCN mRNACTDPMID:31614463
IqcnRatacrylamide decreases expressionISOIQCN (Homo sapiens)6480464Acrylamide results in decreased expression of IQCN mRNACTDPMID:32763439
IqcnRatall-trans-retinoic acid increases expressionISOIQCN (Homo sapiens)6480464Tretinoin results in increased expression of IQCN mRNACTDPMID:23724009
IqcnRataristolochic acid A increases expressionISOIQCN (Homo sapiens)6480464aristolochic acid I results in increased expression of IQCN mRNACTDPMID:33212167
IqcnRatbenzo[a]pyrene increases expressionISOIQCN (Homo sapiens)6480464Benzo(a)pyrene results in increased expression of IQCN mRNACTDPMID:20064835
IqcnRatbenzo[a]pyrene decreases expressionISOIQCN (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of IQCN mRNACTDPMID:32234424
IqcnRatbenzo[a]pyrene affects methylationISOIQCN (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of IQCN promoterCTDPMID:27901495
IqcnRatbenzo[a]pyrene increases methylationISOIQCN (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of IQCN 5' UTRCTDPMID:27901495
IqcnRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of IQCN mRNACTDPMID:25181051
IqcnRatcadmium atom multiple interactionsISOIQCN (Homo sapiens)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IQCN mRNACTDPMID:35301059
IqcnRatcadmium dichloride increases expressionISOIQCN (Homo sapiens)6480464Cadmium Chloride results in increased expression of IQCN mRNACTDPMID:38568856
IqcnRatcadmium dichloride multiple interactionsISOIQCN (Homo sapiens)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IQCN mRNACTDPMID:35301059
IqcnRatcisplatin decreases expressionISOIQCN (Homo sapiens)6480464Cisplatin results in decreased expression of IQCN mRNACTDPMID:27392435
IqcnRatDDE decreases expressionISOIQCN (Homo sapiens)6480464Dichlorodiphenyl Dichloroethylene results in decreased expression of IQCN mRNACTDPMID:38568856
IqcnRatDibutyl phosphate affects expressionISOIQCN (Homo sapiens)6480464di-n-butylphosphoric acid affects the expression of IQCN mRNACTDPMID:37042841
IqcnRatparacetamol increases expressionISOIQCN (Homo sapiens)6480464Acetaminophen results in increased expression of IQCN mRNACTDPMID:29067470
IqcnRatparaquat decreases expressionEXP 6480464Paraquat results in decreased expression of IQCN mRNACTDPMID:32680482
IqcnRatpropionic acid increases expressionISOIQCN (Homo sapiens)6480464propionic acid results in increased expression of IQCN mRNACTDPMID:31526819
IqcnRatsodium arsenite increases expressionISOIQCN (Homo sapiens)6480464sodium arsenite results in increased expression of IQCN mRNACTDPMID:38568856

1 to 20 of 31 rows

Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IqcnRatmitochondrion located_inISOIQCN (Homo sapiens)1624291 RGDGO_REF:0000054

Molecular Function

  


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:21630459  



Iqcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,750,492 - 18,766,184 (-)NCBIGRCr8
mRatBN7.21618,716,519 - 18,733,971 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,716,519 - 18,726,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,758,451 - 18,773,053 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,891,390 - 19,906,139 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,811,400 - 18,826,003 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,467,425 - 20,483,375 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01620,324,493 - 20,339,412 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,222,176 - 19,223,162 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1618,908,707 - 18,924,642 (-)NCBICelera
Cytogenetic Map16p14NCBI
IQCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,257,098 - 18,274,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,257,098 - 18,274,500 (-)EnsemblGRCh38hg38GRCh38
GRCh371918,367,908 - 18,385,262 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,228,908 - 18,246,235 (-)NCBINCBI36Build 36hg18NCBI36
Build 341918,228,907 - 18,246,235NCBI
Celera1918,269,630 - 18,287,045 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,931,567 - 17,948,982 (-)NCBIHuRef
CHM1_11918,368,170 - 18,385,585 (-)NCBICHM1_1
T2T-CHM13v2.01918,391,196 - 18,408,552 (-)NCBIT2T-CHM13v2.0
Iqcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,154,661 - 71,170,299 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,156,106 - 71,170,299 (+)EnsemblGRCm39 Ensembl
GRCm38870,701,321 - 70,717,650 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,703,457 - 70,717,650 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,232,059 - 73,241,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,637,149 - 73,651,080 (+)NCBIMGSCv36mm8
Celera873,264,658 - 73,274,148 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Iqcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555243,181,133 - 3,195,111 (+)NCBIChiLan1.0ChiLan1.0
IQCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,114,554 - 23,132,163 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,122,872 - 22,140,388 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,732,673 - 17,750,226 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,708,154 - 18,719,269 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,708,155 - 18,719,021 (-)Ensemblpanpan1.1panPan2
IQCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,743,889 - 44,758,625 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,745,584 - 44,758,637 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,658,051 - 44,672,793 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,229,714 - 45,244,539 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12044,466,869 - 44,481,627 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,877,601 - 44,892,330 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,152,767 - 45,167,506 (+)NCBIUU_Cfam_GSD_1.0
Iqcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,393,995 - 203,406,713 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,944,534 - 2,955,765 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
IQCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1259,545,325 - 59,558,077 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IQCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,732,296 - 16,745,050 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660742,632,811 - 2,643,498 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iqcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,558,560 - 1,583,275 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Iqcn
75 total Variants

1 to 10 of 28 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat

1 to 10 of 28 rows






Ensembl Acc Id: ENSRNOT00000097349   ⟹   ENSRNOP00000088555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,716,519 - 18,726,261 (-)Ensembl
RefSeq Acc Id: NM_001399437   ⟹   NP_001386366
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,750,492 - 18,765,386 (-)NCBI
mRatBN7.21618,716,519 - 18,731,414 (-)NCBI
RefSeq Acc Id: XM_006252972   ⟹   XP_006253034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,750,492 - 18,766,184 (-)NCBI
mRatBN7.21618,716,519 - 18,733,971 (-)NCBI
Rnor_6.01620,468,408 - 20,483,375 (-)NCBI
Rnor_5.01620,324,493 - 20,339,412 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252973   ⟹   XP_006253035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,750,492 - 18,766,184 (-)NCBI
mRatBN7.21618,716,519 - 18,733,971 (-)NCBI
Rnor_6.01620,468,408 - 20,483,375 (-)NCBI
Rnor_5.01620,324,493 - 20,339,412 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252974   ⟹   XP_006253036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,750,492 - 18,766,184 (-)NCBI
mRatBN7.21618,716,519 - 18,730,829 (-)NCBI
Rnor_6.01620,468,408 - 20,481,651 (-)NCBI
Rnor_5.01620,324,493 - 20,339,412 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600334   ⟹   XP_017455823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,750,492 - 18,766,184 (-)NCBI
mRatBN7.21618,716,519 - 18,733,971 (-)NCBI
Rnor_6.01620,467,425 - 20,482,661 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063274973   ⟹   XP_063131043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,750,492 - 18,766,184 (-)NCBI
RefSeq Acc Id: XM_063274974   ⟹   XP_063131044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,750,492 - 18,766,184 (-)NCBI
RefSeq Acc Id: XM_063274975   ⟹   XP_063131045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,750,492 - 18,766,184 (-)NCBI
RefSeq Acc Id: XM_063274976   ⟹   XP_063131046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,750,492 - 18,766,184 (-)NCBI
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: XP_006253035   ⟸   XM_006252973
- Peptide Label: isoform X1
- UniProtKB: A6KA10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253034   ⟸   XM_006252972
- Peptide Label: isoform X1
- UniProtKB: A6KA10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253036   ⟸   XM_006252974
- Peptide Label: isoform X1
- UniProtKB: A6KA10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455823   ⟸   XM_017600334
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000088555   ⟸   ENSRNOT00000097349


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 21 of 21 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-11799 BioCyc
Ensembl Genes ENSRNOG00000068146 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097349 ENTREZGENE
  ENSRNOT00000097349.1 UniProtKB/TrEMBL
  ENSRNOT00000143459 ENTREZGENE
  ENSRNOT00000156938 ENTREZGENE
Gene3D-CATH 1.20.5.190 UniProtKB/TrEMBL
InterPro CellDiv_DevSignal_Domain UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene LOC102547294 ENTREZGENE
PANTHER PTHR22590:SF2 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam PF00612 UniProtKB/TrEMBL
PhenoGen Iqcn PhenoGen
PROSITE PS50096 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000068146 RatGTEx
SMART SM00015 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6GGC3 ENTREZGENE, UniProtKB/TrEMBL
  A6KA10 ENTREZGENE, UniProtKB/TrEMBL
1 to 21 of 21 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Iqcn  IQ motif containing N  Iqcn  IQ motif containing N  Data merged from RGD:149736523 737654 PROVISIONAL
2021-08-09 Iqcn  IQ motif containing N      Symbol and Name status set to provisional 45752 PROVISIONAL
2017-11-17 Iqcn  IQ motif containing N  LOC102547294  mucin-17-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 LOC102547294  mucin-17-like  LOC306346  similar to KIAA1683  Data merged from RGD:1588554 737654 PROVISIONAL
2013-12-17 LOC102547294  mucin-17-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC306346  similar to KIAA1683      Symbol and Name status set to provisional 70820 PROVISIONAL